Dioscuri Centre for Single-Molecule Optics

Provider

Ministry of Education, Youth and Sports

Programme

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Call for proposals

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Main participants

Fyzikální ústav AV ČR, v. v. i.

Contest type

M2 - International cooperation

Contract ID

MSMT-22055/2023-6

Project name in Czech

Dioscuri Centre for Single-Molecule Optics

Annotation in Czech

Biomolecules are the fundamental building blocks of every organism. Yet, there is still a myriad of molecular processes that remain elusive, creating significant roadblocks in, for example, medical research. Biomolecules possess heterogeneities of high physiological relevance that can only be unravelled using single-molecule tools. However, the available tools often do not provide quantitative information and require fluorescent labelling or immobilization onto a surface, possibly altering the biomolecule’s natural behaviour. Dioscuri Centre (DC) will focus on developing next-generation life-science tools that can bypass those limitations and thus significantly contribute to the fundamental understanding of molecular processes pervading biological systems. DC will develop a unique experimental toolbox for multiparametric characterization of biomolecular processes at a single-molecule level without the need for any labelling or attachment onto a surface. The tools will build on the principles of Nanofluidic Scattering Microscopy - a ground-breaking optical microscopy technique that has been recently introduced. The developed tools will be used for various applications, including investigation of biomolecular interactions, aggregation processes, molecular transport, or single-cell analysis. The research will inspire new strategies for early diagnosis and therapeutic intervention, plus the invention of new biotechnologies mimicking nature.

R&D category

ZV - Basic research

OECD FORD - main branch

10306 - Optics (including laser optics and quantum optics)

OECD FORD - secondary branch

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OECD FORD - another secondary branch

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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

BH - Optics, masers and lasers

Realization period - beginning

Jul 1, 2024

Realization period - end

Jun 30, 2029

Project status

B - Running multi-year project

Latest support payment

Oct 4, 2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP25-MSM-LV-R

Data delivery date

Feb 20, 2025

Total approved costs

38,860 thou. CZK

Public financial support

35,874 thou. CZK

Other public sources

0 thou. CZK

Non public and foreign sources

2,989 thou. CZK