CDC25 phosphatases ? key regulator of mammalian oocytec maturation and early embryonic development
Public support
Provider
Ministry of Education, Youth and Sports
Programme
KONTAKT
Call for proposals
KONTAKT 6 (SMSM2008ME3)
Main participants
—
Contest type
VS - Public tender
Contract ID
1323/2010-32
Alternative language
Project name in Czech
CDC25 fosfatázy - klíčové regulátory meiotického zrání savčích oocytů a raného embryonálního vývoje
Annotation in Czech
Charakterizace role CDC25A během meiózy a raného embryonálního vývoje, Definice klíčové signalizace regulující aktivitu CDC25B během znovuzahájení meiózy, Prozkoumání vzájemné koordinace CDC25A a CDC25B během meiózy
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
EB - Genetics and molecular biology
CEP - secondary branch
ED - Physiology
CEP - another secondary branch
FK - Gynaecology and obstetrics
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30105 - Physiology (including cytology)<br>30214 - Obstetrics and gynaecology
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
On the base of Czech-US scientific cooperation program we showed the key role of CDC25A in oocytes meiosis. We uncovered the function of AURKA during both in vitro and in vivo meiotic maturation and the role of AURKA in spindle formation and MTOC biogenesis. We suggested the important role of different localization of CDK1 regulators during resumption of meiosis. We published 5 scientific papers.
Solution timeline
Realization period - beginning
Jan 1, 2008
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Mar 14, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-MSM-ME-U/01:1
Data delivery date
Jul 12, 2012
Finance
Total approved costs
3,328 thou. CZK
Public financial support
1,600 thou. CZK
Other public sources
1,728 thou. CZK
Non public and foreign sources
0 thou. CZK