Interplay between mitochondrial function and aging in yeast: molecular and cell-biological approach
Public support
Provider
Ministry of Education, Youth and Sports
Programme
KONTAKT
Call for proposals
KONTAKT 7 (SMSM2009ME4)
Main participants
—
Contest type
VS - Public tender
Contract ID
2060/2011-320
Alternative language
Project name in Czech
Vzájemné vztahy mezi funkcí mitochondrií a stárnutím u kvasinek z pohledu molekulární a buněčné biologie
Annotation in Czech
Získat poznatky o úloze mitochondrií v procesu stárnutí na úrovni buněčné a molekulární biologie. S použitím modelového organismu kvasinek identifikovat důležité geny a pochody mající rozhodující úlohu ve funkci mitochondrií vedoucí ke stárnutí.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
EB - Genetics and molecular biology
CEP - secondary branch
EE - Microbiology, virology
CEP - another secondary branch
—
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10606 - Microbiology<br>10607 - Virology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
Important aspect of the involvement of mitochondria in the aging process of the yeast S. cerevisiae is their morphological structure, which determines its overall function represented as respiration rate. Genetic manipulation in the order to stabilize mitochondrial tubules or prevent mitophagie did?t lead to prolongation of cell viability and caused the increasing heterogeneity of the population.
Solution timeline
Realization period - beginning
Apr 1, 2009
Realization period - end
Dec 31, 2012
Project status
U - Finished project
Latest support payment
Feb 23, 2012
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP13-MSM-ME-U/01:1
Data delivery date
Jun 28, 2013
Finance
Total approved costs
2,000 thou. CZK
Public financial support
2,000 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK