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ME09043

Interplay between mitochondrial function and aging in yeast: molecular and cell-biological approach

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    KONTAKT

  • Call for proposals

    KONTAKT 7 (SMSM2009ME4)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    2060/2011-320

Alternative language

  • Project name in Czech

    Vzájemné vztahy mezi funkcí mitochondrií a stárnutím u kvasinek z pohledu molekulární a buněčné biologie

  • Annotation in Czech

    Získat poznatky o úloze mitochondrií v procesu stárnutí na úrovni buněčné a molekulární biologie. S použitím modelového organismu kvasinek identifikovat důležité geny a pochody mající rozhodující úlohu ve funkci mitochondrií vedoucí ke stárnutí.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    EB - Genetics and molecular biology

  • CEP - secondary branch

    EE - Microbiology, virology

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10606 - Microbiology<br>10607 - Virology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Important aspect of the involvement of mitochondria in the aging process of the yeast S. cerevisiae is their morphological structure, which determines its overall function represented as respiration rate. Genetic manipulation in the order to stabilize mitochondrial tubules or prevent mitophagie did?t lead to prolongation of cell viability and caused the increasing heterogeneity of the population.

Solution timeline

  • Realization period - beginning

    Apr 1, 2009

  • Realization period - end

    Dec 31, 2012

  • Project status

    U - Finished project

  • Latest support payment

    Feb 23, 2012

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP13-MSM-ME-U/01:1

  • Data delivery date

    Jun 28, 2013

Finance

  • Total approved costs

    2,000 thou. CZK

  • Public financial support

    2,000 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK