New glycosynthases and their use in glycoconjugates synthesis
Public support
Provider
Ministry of Education, Youth and Sports
Programme
KONTAKT
Call for proposals
—
Main participants
—
Contest type
M2 - International cooperation
Contract ID
6094/2009-32
Alternative language
Project name in Czech
Nové glykosynthasy a jejich využití pro syntézu glykokonjugátů
Annotation in Czech
Cílem projektu je získat pomocí cílené mutagenese mikrobiální galaktosynthasu, jež by byla schopna katalyzovat transglykosylaci donorů připravených chemickou syntézou. Tímto způsobem získat konjugáty obsahující furanosu, které by byly vhodné pro farmaceutické účely.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
CE - Biochemistry
CEP - secondary branch
EB - Genetics and molecular biology
CEP - another secondary branch
FR - Pharmacology and apothecary chemistry
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30104 - Pharmacology and pharmacy
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Unique furanose-containing glycoconjugates were prepared. Several of them showed an ability to increase the macrophage TNF-? production. This property might be a basis for their future application as a vaccines against serious deseases.
Solution timeline
Realization period - beginning
Jan 1, 2008
Realization period - end
Dec 31, 2009
Project status
U - Finished project
Latest support payment
Apr 1, 2009
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP10-MSM-ME-U/01:1
Data delivery date
Jun 30, 2010
Finance
Total approved costs
100 thou. CZK
Public financial support
100 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK