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NB7517

Effect of insulin and free fatty acids on the production of selected cytokines in adipose tissue in type 2 diabetic patients and healthy subjects.

Public support

  • Provider

    Ministry of Health

  • Programme

    Research and development in the sphere of nutrition, metabolic and endocrine diseases

  • Call for proposals

    Výzkum a vývoj v oblasti Kardiovaskulárních chorob 5 (SMZ02003NB)

  • Main participants

    Institut klinické a experimentální medicíny

  • Contest type

    VS - Public tender

  • Contract ID

Alternative language

  • Project name in Czech

    Vliv inzulinu a zvýšení volných mastných kyselin na produkci vybraných cytokinů v tukové tkáni u nemocných s diabetem 2. typu a zdravých osob.

  • Annotation in Czech

    Cílem studie je sledovat roli inzulinu a volných mastných kyselin v regulaci exprese genů pro adiponectin, resistin, TNF a SREBP1 v tukové tkáni a na sérové koncentrace adiponectinu, resistinu a leptinu u diabetiků 2. typu a zdravých osob.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FB - Endocrinology, diabetology, metabolism, nutrition

  • CEP - secondary branch

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Acute in vivo induced hyperinsulinemia/ or elevation of free fatty acids alters the production of selected adipokines. The study documents the role of adipokines in lipid- and insulin- induced insulin resistance in humans.

Solution timeline

  • Realization period - beginning

    Jan 1, 2003

  • Realization period - end

    Jan 1, 2005

  • Project status

    U - Finished project

  • Latest support payment

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP06-MZ0-NB-U/01:1

  • Data delivery date

    Jun 23, 2006

Finance

  • Total approved costs

    4,929 thou. CZK

  • Public financial support

    4,694 thou. CZK

  • Other public sources

    59 thou. CZK

  • Non public and foreign sources

    4 thou. CZK