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NR7860

Study of apoptosis inhibitors as diagnostic and predictive tumor biomarkers in lung cancer

Project goals

Analysis of expression of apoptosis inhibitors by molecular and biochemical methods in tumor tissue, lung parenchyma, biopsy and cytological samples and sputum from lung cancer patients and study of their significance as tumor biomarkers in lung cancer.

Keywords

Lung cancerTumor cell apoptosisInhibitor of apoptosisTumor biomarkerSurvivinCaspase-9SProteinase inhibitor-9Apoptosome

Public support

  • Provider

    Ministry of Health

  • Programme

    Branch programm of research of the Ministry of Health

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví 1 (SMZ02004NR)

  • Main participants

    —

  • Contest type

    VS - Public tender

  • Contract ID

    NR7860-5/2004

Alternative language

  • Project name in Czech

    Studium inhibitorů apoptosy jako diagnostických a prediktivních nádorových biomarkerů u karcinomu plic

  • Annotation in Czech

    Analýza exprese inhibitorů apoptosy molekulárně-biochemickými metodami v nádo-rech plic, plicním parenchymu, bioptických a cytologických vzorcích a sputu od pacientů s karcinomem plic a studium jejich významu jako nádorových biomarkerů u karcinomu plic.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FD - Oncology and haematology

  • CEP - secondary branch

    —

  • CEP - another secondary branch

    —

  • 30204 - Oncology
    30205 - Hematology

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    Results of the project has enabled precision prediction of therapeutic response in NSCLC (non-small cell lung cancer), with subsequent modulation of treatment options.

Solution timeline

  • Realization period - beginning

    Jan 1, 2004

  • Realization period - end

    Dec 31, 2008

  • Project status

    U - Finished project

  • Latest support payment

    Mar 5, 2008

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP09-MZ0-NR-U/09:2

  • Data delivery date

    Apr 27, 2011

Finance

  • Total approved costs

    9,173 thou. CZK

  • Public financial support

    8,553 thou. CZK

  • Other public sources

    501 thou. CZK

  • Non public and foreign sources

    0 thou. CZK

Basic information

Recognised costs

9 173 CZK thou.

Public support

8 553 CZK thou.

93%

Provider

Ministry of Health

CEP

FD - Oncology and haematology

Solution period

01. 01. 2004 - 31. 12. 2008

Similar projects(10)

Study of apoptosis in human nonsmall cell lung cancer (NC4963) Detection of activated ras oncogenes in non-small-cell lung carcinoma and in premalignant changes of the respiratory epithelium (IZ2290) Transcription factor MITF in melanoma and transcription factor HASH1 in small cell lung carcinoma (NR8026)