The role of interaction of cytochrome P-450 metabolites and the renin-angiotensin system in the control of renal function

Provider

Ministry of Health

Programme

Branch programm of research of the Ministry of Health

Call for proposals

VaV pro Ministerstvo zdravotnictví 2 (SMZ02005NR)

Main participants

—

Contest type

VS - Public tender

Contract ID

NR8271-3/2005

Project name in Czech

Úloha intrarenální interakce cytochromu P-450 a renin-angiotenzinového systému v regulaci renálních funkcí a rozvoji angiotenzin II-dependentní formy hypertenze

Annotation in Czech

Bude studována úloha interakce metabolitů cytochromu P-450 a renin-angiotenzinového systému v regulaci renálních funkcí a rozvoji angiotenzin II-dependentní formy hypertenze.

R&D category

NV - Nonindustrial research (Applied research excluded Industrial research)

CEP classification - main branch

FP - Other medical fields

CEP - secondary branch

FR - Pharmacology and apothecary chemistry

CEP - another secondary branch

FA - Cardiovascular diseases including cardio-surgery

OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

30104 - Pharmacology and pharmacy<br>30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30201 - Cardiac and Cardiovascular systems<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science

Provider evaluation

V - Vynikající výsledky projektu (s mezinárodním významem atd.)

Project results evaluation

It has been proved that angiotenzin II ? dependent forms of hypertension causes over production of 20-HETE in vascular bed and relative deficit of creation of vasodilating and natriuretic EETs in vascular bed and tubular apparatus of kidneys.

Realization period - beginning

Jan 1, 2005

Realization period - end

Dec 31, 2007

Project status

U - Finished project

Latest support payment

Mar 1, 2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP08-MZ0-NR-U/03:1

Data delivery date

Sep 16, 2008

Total approved costs

4,904 thou. CZK

Public financial support

4,773 thou. CZK

Other public sources

131 thou. CZK

Non public and foreign sources

0 thou. CZK