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NR8576

The role of peripheral metabolism of glucocorticoids in inflammation-induced changes in humans and animal model of inflammatory bowel disease

Public support

  • Provider

    Ministry of Health

  • Programme

    Branch programm of research of the Ministry of Health

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví 2 (SMZ02005NR)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NR8576-3/2005

Alternative language

  • Project name in Czech

    Úloha periferního metabolismu glukokortikoidů u idiopathických střevních zánětů u lidí a v experimentálním zvířecím modelu

  • Annotation in Czech

    Na zvířecím modelu zánětlivých střevních chorob bude stanovena tkáňová koncentrace metabolitů steroidů a aktivity 11 HSD budou stanoveny v homogenátech. Exprese mRNA 11HSD 1 a mRNA 11HSD2 bude stanovena RT-PCR. Separace imunitních buněk densitní centrifugací a imunomagnetickou selekcí.Monitorace koncentrace PEG2 a exprese COX-2 a PLA2 v buněčných kulturách enterocytů.Inhibice periferního metabolismu glukokortikoidů u experimentálních modelů.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FB - Endocrinology, diabetology, metabolism, nutrition

  • CEP - secondary branch

    FE - Other fields of internal medicine

  • CEP - another secondary branch

    ED - Physiology

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30105 - Physiology (including cytology)<br>30202 - Endocrinology and metabolism (including diabetes, hormones)<br>30217 - Urology and nephrology<br>30218 - General and internal medicine<br>30219 - Gastroenterology and hepatology<br>30220 - Andrology

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    The authors have proved the task of 11 beta-hydroxysteroid dehydrogenasis in local metabolism of corticoids. The project was fully managed both from the methodological point of view and its clinical application.

Solution timeline

  • Realization period - beginning

    Jan 1, 2005

  • Realization period - end

    Dec 31, 2007

  • Project status

    U - Finished project

  • Latest support payment

    Mar 2, 2007

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP08-MZ0-NR-U/03:1

  • Data delivery date

    Sep 16, 2008

Finance

  • Total approved costs

    3,732 thou. CZK

  • Public financial support

    3,607 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    62 thou. CZK