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NR8913

The expression of proinflammatory genes in patients with IgA nephropathy and their relation to the disease outcome

Public support

  • Provider

    Ministry of Health

  • Programme

    Branch programm of research of the Ministry of Health

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví 3 (SMZ02006NR)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NR8913-4/2006

Alternative language

  • Project name in Czech

    Exprese prozánětlivých genů u nemocných s IgA nefropatií a jejich vztah k průběhu onemocnění

  • Annotation in Czech

    Sledovat korelaci mezi intrarenální expresí genů pro MCP-1, RANTES, TGFbeta1, HGF a BMP, infiltací ledvinné tkáně leukocyty, výší proteinurie a progrese IgA nefropatie Zjistit, zda nositelé vlohy pro vysokou produkci prozánětlivých cytokinů mají vyšší riziko vzniku klinicky závažné proteinurie a progrese IgA nefropatie

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FE - Other fields of internal medicine

  • CEP - secondary branch

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30217 - Urology and nephrology<br>30218 - General and internal medicine<br>30219 - Gastroenterology and hepatology<br>30220 - Andrology

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Analysis of gene expression of selected molecular markers in kidney tissue revealed higher predictive significance in progression of studied nephropathies, compared to standard markers and risk factors of progression.

Solution timeline

  • Realization period - beginning

    Jan 1, 2006

  • Realization period - end

    Dec 31, 2009

  • Project status

    U - Finished project

  • Latest support payment

    Dec 18, 2009

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP10-MZ0-NR-U/03:3

  • Data delivery date

    Apr 27, 2011

Finance

  • Total approved costs

    4,966 thou. CZK

  • Public financial support

    4,432 thou. CZK

  • Other public sources

    534 thou. CZK

  • Non public and foreign sources

    0 thou. CZK