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NR8987

A-204C polymorphism and regulation of cholesterol 7alpha-hydroxylase activity

Public support

  • Provider

    Ministry of Health

  • Programme

    Branch programm of research of the Ministry of Health

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví 3 (SMZ02006NR)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NR8987-3/2006

Alternative language

  • Project name in Czech

    Polymorfismus A-204C a regulace aktivity cholesterol 7alfa-hydroxylázy

  • Annotation in Czech

    Cirkadiánní variace v aktivitě cholesterol 7alfa-hydroxylázy (CYP7A1) bude studována u zdravých dobrovolníků homozygotních pro variantu -204A nebo -204C v promotoru genu pro CYP7A1. Cirkadiánní variace v aktivitě CYP7A1 bude studována za bazálních podmínek a po stimulaci nebo inhibici exprese genu pro CYP7A1 pomocí léků (colestipolu a kyseliny chenodeoxycholové). Aktivita obou variant promotoru genu pro CYP7A1 bude studována in vitro technikou duální luciferázové eseje jak za bazálních podmínek, tak postimulaci.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FB - Endocrinology, diabetology, metabolism, nutrition

  • CEP - secondary branch

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    The solution brough new evidence for genetically dependent differences in the response of organism to cholesterol intake in diet and contributed to understanding of the role of insulin in regulation of the key enzyme in cholesterol metabolism

Solution timeline

  • Realization period - beginning

    Jan 1, 2006

  • Realization period - end

    Dec 31, 2008

  • Project status

    U - Finished project

  • Latest support payment

    Mar 5, 2008

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP09-MZ0-NR-U/09:2

  • Data delivery date

    Apr 27, 2011

Finance

  • Total approved costs

    3,917 thou. CZK

  • Public financial support

    3,599 thou. CZK

  • Other public sources

    318 thou. CZK

  • Non public and foreign sources

    0 thou. CZK