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NR9401

The role of dietary cholesterol in regulation of gene expression in the model of dietary induced hypercholesterolemia

Public support

  • Provider

    Ministry of Health

  • Programme

    Branch programm of research of the Ministry of Health

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví 4 (SMZ02007NR)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NR9401-3/2007

Alternative language

  • Project name in Czech

    Úloha cholesterolu v regulaci genové exprese v játrech v modelu dietou indukované hypercholesterolémie

  • Annotation in Czech

    Exprese genů, které odpovídají na dietní cholesterol, a genů, které jsou odpovědné za rozvoj hypercholesterolémie, bude studována na modelu dietou indukované hypercholesterolémie - u Pražského hereditárně hypercholesterolemického (PHHC) potkana. Budou studovány mechanismy vedoucí k vzestupu koncentrace cholesterolu ve VLDL, IDL a LDL u Pražského hereditárně hypercholesterolemického (PHHC) potkana po zátěži dietním cholesterolem.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FB - Endocrinology, diabetology, metabolism, nutrition

  • CEP - secondary branch

    EB - Genetics and molecular biology

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30202 - Endocrinology and metabolism (including diabetes, hormones)

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Results of a study on laboratory rats, which was focused on identification of hepatic genes contributing to diffrential response to dieatry cholesterol. Results are largely negative, but few novel genes were found.

Solution timeline

  • Realization period - beginning

    Jan 1, 2007

  • Realization period - end

    Dec 31, 2009

  • Project status

    U - Finished project

  • Latest support payment

    Dec 18, 2009

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP10-MZ0-NR-U/03:3

  • Data delivery date

    Apr 27, 2011

Finance

  • Total approved costs

    4,928 thou. CZK

  • Public financial support

    4,857 thou. CZK

  • Other public sources

    71 thou. CZK

  • Non public and foreign sources

    0 thou. CZK