The role of dietary cholesterol in regulation of gene expression in the model of dietary induced hypercholesterolemia
Public support
Provider
Ministry of Health
Programme
Branch programm of research of the Ministry of Health
Call for proposals
VaV pro Ministerstvo zdravotnictví 4 (SMZ02007NR)
Main participants
—
Contest type
VS - Public tender
Contract ID
NR9401-3/2007
Alternative language
Project name in Czech
Úloha cholesterolu v regulaci genové exprese v játrech v modelu dietou indukované hypercholesterolémie
Annotation in Czech
Exprese genů, které odpovídají na dietní cholesterol, a genů, které jsou odpovědné za rozvoj hypercholesterolémie, bude studována na modelu dietou indukované hypercholesterolémie - u Pražského hereditárně hypercholesterolemického (PHHC) potkana. Budou studovány mechanismy vedoucí k vzestupu koncentrace cholesterolu ve VLDL, IDL a LDL u Pražského hereditárně hypercholesterolemického (PHHC) potkana po zátěži dietním cholesterolem.
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
FB - Endocrinology, diabetology, metabolism, nutrition
CEP - secondary branch
EB - Genetics and molecular biology
CEP - another secondary branch
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OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30202 - Endocrinology and metabolism (including diabetes, hormones)
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
Results of a study on laboratory rats, which was focused on identification of hepatic genes contributing to diffrential response to dieatry cholesterol. Results are largely negative, but few novel genes were found.
Solution timeline
Realization period - beginning
Jan 1, 2007
Realization period - end
Dec 31, 2009
Project status
U - Finished project
Latest support payment
Dec 18, 2009
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP10-MZ0-NR-U/03:3
Data delivery date
Apr 27, 2011
Finance
Total approved costs
4,928 thou. CZK
Public financial support
4,857 thou. CZK
Other public sources
71 thou. CZK
Non public and foreign sources
0 thou. CZK