Study of relation between expression profiles in tumor tissue and result of chemotherapy of breast carcinomas
Project goals
Major aim of this project is search for markers of prediction of breast cancer chemotherapy result. Differences in expression of groups of functionally relevant genes will be followed in tumors of patients and compared to chemotherapy outcomes. Revealedpredictive markers will be validated by confirmation of mechanism of action using analysis of genetic polymorphism and phenotype of corresponding proteins. The project will continue in previous studies of principal investigator in the same area.
Keywords
cancerbreastchemotherapypredictionmetabolismgenomicsgenotypephenotype
Public support
Provider
Ministry of Health
Programme
Departmental Programme of Research and Development - MH II from 2008 to 2011
Call for proposals
VaV pro Ministerstvo zdravotnictví II 1 (SMZ0200801)
Main participants
—
Contest type
VS - Public tender
Contract ID
NS9799-4/2008
Alternative language
Project name in Czech
Sledování účinnosti léčby karcinomu prsu v závislosti na expresních profilech v nádorové tkáni
Annotation in Czech
Cílem projektu je nalezení ukazatelů predikce výsledku chemoterapie u pacientek s karcinomem prsu. V nádorech pacientek budou hledány rozdíly v expresi funkčně důležitých skupin genů a současně bude hodnocena léčebná odpověď na standartní chemoterapii. Nalezené ukazaltele budou validovány pomocí studia mechanismu jejich působení analýzou genetického polymorfismu a fenotypu odpovídajících proteinů. Projekt naváže na řadu studií již rozpracovaných řešitelským pracovištěm.
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
FR - Pharmacology and apothecary chemistry
CEP - secondary branch
EB - Genetics and molecular biology
CEP - another secondary branch
FD - Oncology and haematology
10603 - Genetics and heredity (medical genetics to be 3)
10604 - Reproductive biology (medical aspects to be 3)
10605 - Developmental biology
10608 - Biochemistry and molecular biology
10609 - Biochemical research methods
30101 - Human genetics
30104 - Pharmacology and pharmacy
30204 - Oncology
30205 - Hematology
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
A number of candidate genetic biomarkers of bread cancer prognosis and chemotherapy efficacy was discovered in the frame of this project.SOD3, ABCC8 and PRC1 belong to the most interesting candidates.Validity,utility will be evalued in follow up studies.
Solution timeline
Realization period - beginning
Jul 1, 2008
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Aug 8, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-MZ0-NS-U/09:3
Data delivery date
Oct 31, 2013
Finance
Total approved costs
4,843 thou. CZK
Public financial support
4,843 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Basic information
Recognised costs
4 843 CZK thou.
Public support
4 843 CZK thou.
100%
Provider
Ministry of Health
CEP
FR - Pharmacology and apothecary chemistry
Solution period
01. 07. 2008 - 31. 12. 2011