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NS9935

Molecular pathophysiology of congenital defects of red blood cell production

Public support

  • Provider

    Ministry of Health

  • Programme

    Departmental Programme of Research and Development - MH II from 2008 to 2011

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví II 1 (SMZ0200801)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    NS9935-3/2008

Alternative language

  • Project name in Czech

    Molekulární patofyziologie vybraných vrozených poruch erytropoézy

  • Annotation in Czech

    Molekulárně-genetická diagnostika hemoglobinopatií, talasemií a vrozených polycytémií v České republice. Analýza klíčových enzymatických procesů eliminujících volné radikály u vybraných poruch se známkami oxidačního stresu v erytrocytech. Funkční analýzaúspěšnosti léčby nemocného s vrozenou poruchou transportu iontů železa v erytroidních buňkách.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    EB - Genetics and molecular biology

  • CEP - secondary branch

    FD - Oncology and haematology

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30204 - Oncology<br>30205 - Hematology

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Authors characterized on a molecular level several congenital defects of erythropoiesis in the patients from Czech Rep. Their results lead to improved therapy of these patients and provided new insights into molecular pathophysiology of erythropoiesis.

Solution timeline

  • Realization period - beginning

    Jul 1, 2008

  • Realization period - end

    Dec 31, 2010

  • Project status

    U - Finished project

  • Latest support payment

    Jul 16, 2010

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP11-MZ0-NS-U/04:2

  • Data delivery date

    Jan 10, 2012

Finance

  • Total approved costs

    7,607 thou. CZK

  • Public financial support

    4,431 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    3,176 thou. CZK