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NT14325

The role of inflammation in the pathogenesis of diabetes and organ damage: possibilities of pharmaceutical interventions

Project goals

The project is focused on the analysis of the role of inflammatory processes in the pathogenesis of diabetic complications in patients with type 2 diabetes and heart failure. We will specifically study the anti-inflammatory effects of metformin. In addition, in transgenic spontaneously hypertensive rats (SHR) expressing human C-reactive protein, we will test the effects of metformin or combinations of statins with fibrates or niacin on amelioration of target organ damage.

Keywords

type 2 diabetesinflammationC reactive proteincardiac failuretransgenic ratmetforminstatins

Public support

  • Provider

    Ministry of Health

  • Programme

    Ministry of Health?s Departmental Research and Development Programme III

  • Call for proposals

    VaV pro Ministerstvo zdravotnictví III 4 (SMZ0201301)

  • Main participants

    —

  • Contest type

    VS - Public tender

  • Contract ID

    NT14325-3/2013

Alternative language

  • Project name in Czech

    Úloha zánětlivých procesů v patogenezi diabetu a orgánového poškození: možnosti farmakologické intervence

  • Annotation in Czech

    Projekt se zabývá analýzou úlohy zánětlivých procesů v patogenezi diabetických komplikací u pacientů s diabetem 2. typu a se srdečním selháním. Specificky budou analyzovány protizánětlivé účinky metforminu. Dále u transgenních spontánně hypertenzních potkanů kmene SHR, exprimujících lidský C reaktivní protein, budou studovány účinky metforminu nebo statinů v kombinaci s fibráty nebo niacinem na reverzi poškození srdce, ledvin a jater.

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FB - Endocrinology, diabetology, metabolism, nutrition

  • CEP - secondary branch

    —

  • CEP - another secondary branch

    —

  • 30202 - Endocrinology and metabolism (including diabetes, hormones)

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    The project explored the role of inflammatory processes in the pathogenesis of diabetes and organ damage and examined the possibilities of their pharmacological modulation.

Solution timeline

  • Realization period - beginning

    May 1, 2013

  • Realization period - end

    Dec 31, 2015

  • Project status

    U - Finished project

  • Latest support payment

    Mar 20, 2015

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP16-MZ0-NT-U/02:1

  • Data delivery date

    Dec 19, 2016

Finance

  • Total approved costs

    5,897 thou. CZK

  • Public financial support

    5,897 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK

Basic information

Recognised costs

5 897 CZK thou.

Public support

5 897 CZK thou.

100%

Provider

Ministry of Health

CEP

FB - Endocrinology, diabetology, metabolism, nutrition

Solution period

01. 05. 2013 - 31. 12. 2015

Similar projects(10)

Mitochondrial targeting as efficient treatment of pancreatic cancer and type 2 diabetes mellitus (NV16-31604A) Effects of metabolic protection on heart failure in type 2 diabetes (NT14250) Effects of omega-3 polyunsaturated fatty acids in type 2 diabetic patients – new mechanisms for targeted therapy (NT13763)