Bioactive nanostructured surfaces for histocompatible implants
Public support
Provider
Ministry of Health
Programme
Programme to support medical applied research in 2015 to 2022
Call for proposals
Zdravotnický AV 1 (SMZ0201501)
Main participants
Fyziologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
15-32497A
Alternative language
Project name in Czech
Bioaktivní nanostrukturované povrchy pro histokompatibilní implantáty
Annotation in Czech
V tomto mezioborovém projektu budou připraveny inovované diamantové povlaky kostních a cévních implantátů pro zvýšení jejich histokompatibility při biomedicínských aplikacích. Implantáty budou založeny na kovech běžně užívaných v medicíně (Ti, Ti-6Al-4V, nerez ocel). Pro další zlepšení funkce budou navíc zkoumány nové materiály s nanočásticemi zlata a diamantu, polymery, samonosnými diamantovými strukturami a jejich kompozity. Hierarchicky organizovaná mikro- a nanostruktura implantátů, jejich povrchové chemické složení a smáčivost budou optimalizovány pomocí laseru a plazmatu. Implantáty budou dále funkcionalizovány kostním morfogenetickým proteinem-7 (BMP-7) pro zvýšení jejich osteointegrace nebo heparinem pro zvýšení regenerace endotelu a prevenci restenózy. Nově vyvinuté materiály budou testovány in vitro především z hlediska imunitní aktivace buněk. Vybrané materiály pak budou implantovány in vivo do tibie a krčních tepen králíka a následně bude histologicky sledována reakce přilehlých i vzdálených tkání.
Scientific branches
R&D category
AP - Applied research
CEP classification - main branch
FJ - Surgery including transplantology
CEP - secondary branch
EI - Biotechnology and bionics
CEP - another secondary branch
EA - Morphology and cytology
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10601 - Cell biology<br>10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology<br>20801 - Environmental biotechnology<br>20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management<br>20803 - Environmental biotechnology related ethics<br>20901 - Industrial biotechnology<br>20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation<br>20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials<br>30212 - Surgery<br>30213 - Transplantation<br>30401 - Health-related biotechnology<br>30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)<br>30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])<br>30404 - Biomaterials (as related to medical implants, devices, sensors)<br>30405 - Medical biotechnology related ethics<br>40401 - Agricultural biotechnology and food biotechnology<br>40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming<br>40403 - Agricultural biotechnology related ethics
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
Project has fulfilled all expected plans and in some aspects even overcome the number of expected results (Jimp planed 6, realized 15): Outcome of the project is 15 impacted papers (14 published, 1 accepted), 4 articles in abstract book, 2 chapters in scientific book, 3 prototypes and 3 functional technologies (samples). During the project works a number of material samples was created and tested, also several carriers and implants with improved histocompatibility. Some of created samples/implants were also tested “in-vivo” (with rabbits or fertilized chicken eggs) and there are prepared for potential preclinical tests on bigger animals and clinical tests. Newly developed implants are perspective due to better integration of the implants and therefore faster patient recovery. The work on the project included activity of material research engineering, biology, veterinary and clinical research. Obtained results are therefore important not only for basic research but also for applicati
Solution timeline
Realization period - beginning
May 1, 2015
Realization period - end
Dec 31, 2018
Project status
U - Finished project
Latest support payment
Jun 28, 2018
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP19-MZ0-NV-U/01:1
Data delivery date
Jun 28, 2019
Finance
Total approved costs
19,476 thou. CZK
Public financial support
19,476 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK