Transport of cations and protons across biomembranes - molecular structure and activity mechanism of Na+/H+ antiporter from lower eukaryotes
Public support
Provider
Ministry of Education, Youth and Sports
Programme
COST
Call for proposals
COST 8 (SMSM2010OC5)
Main participants
—
Contest type
VS - Public tender
Contract ID
1081/2011-320
Alternative language
Project name in Czech
Transport kationtů a protonů přes buněčné membrány - molekulární struktura a mechanismus aktivity Na+/H+ antiporterů nižších eukaryot.
Annotation in Czech
Cílem projektu je objasnění molekulárního mechanismu výměny kationtů alkalických kovů za protony při transportu přes plasmatickou membránu nižších eukaryot antiporterterem typu Nha1.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
CE - Biochemistry
CEP - secondary branch
EB - Genetics and molecular biology
CEP - another secondary branch
EE - Microbiology, virology
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10606 - Microbiology<br>10607 - Virology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
Amino-acid residues involved in the substrate specificity and activity of the yeast Nha1/Sod2-22 antiporters are localized in transmembrane segments 4,5 and 11, and in the hydrophilic C-terminus in the close vicinity and contribute to the binding and transport of cations and protons. Our results contribute to the understanding of maintenance of cation and pH homeostases in lov/er eukaryotes.
Solution timeline
Realization period - beginning
May 1, 2010
Realization period - end
Dec 31, 2012
Project status
U - Finished project
Latest support payment
Feb 27, 2012
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP13-MSM-OC-U/01:1
Data delivery date
Jun 28, 2013
Finance
Total approved costs
3,205 thou. CZK
Public financial support
1,442 thou. CZK
Other public sources
1,763 thou. CZK
Non public and foreign sources
0 thou. CZK