Application of DNA methylation arrays for assessment of aberrantly methylated genes in MDS and AML patients
Public support
Provider
Ministry of Education, Youth and Sports
Programme
COST
Call for proposals
COST 8 (SMSM2010OC5)
Main participants
—
Contest type
VS - Public tender
Contract ID
1081/2011-320
Alternative language
Project name in Czech
Studium aberantně metylovaných genů u pacientů s MDS a AML pomocí DNA metylačních arrayí.
Annotation in Czech
Na základě našich předběžných výsledků a údajů z literatury chceme získat nové informace o epigenetické regulaci leukemogeneze AML a progrese MDS a tím přispět k individualizaci a zvýšení účinnosti léčby AML a MDS. (max.255 znaků)
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FD - Oncology and haematology
CEP - secondary branch
FP - Other medical fields
CEP - another secondary branch
EB - Genetics and molecular biology
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30204 - Oncology<br>30205 - Hematology<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
DNA methylation status of selected genes was correlated with patients' prognosis and mutational status of DNMT3A gene. We found influence of DNA methylation on overall survival and incidence of relapses as well as relationship between DNMT3A mutations and DNA methylation. Further we performed whole genome bisulfite sequencing and expression profiling to reveal the complex role of DNA methylation.
Solution timeline
Realization period - beginning
May 1, 2010
Realization period - end
Nov 30, 2012
Project status
U - Finished project
Latest support payment
Feb 27, 2012
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP13-MSM-OC-U/01:1
Data delivery date
Jun 28, 2013
Finance
Total approved costs
2,400 thou. CZK
Public financial support
2,100 thou. CZK
Other public sources
300 thou. CZK
Non public and foreign sources
0 thou. CZK