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OC10042

Application of DNA methylation arrays for assessment of aberrantly methylated genes in MDS and AML patients

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    COST

  • Call for proposals

    COST 8 (SMSM2010OC5)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    1081/2011-320

Alternative language

  • Project name in Czech

    Studium aberantně metylovaných genů u pacientů s MDS a AML pomocí DNA metylačních arrayí.

  • Annotation in Czech

    Na základě našich předběžných výsledků a údajů z literatury chceme získat nové informace o epigenetické regulaci leukemogeneze AML a progrese MDS a tím přispět k individualizaci a zvýšení účinnosti léčby AML a MDS. (max.255 znaků)

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    FD - Oncology and haematology

  • CEP - secondary branch

    FP - Other medical fields

  • CEP - another secondary branch

    EB - Genetics and molecular biology

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30204 - Oncology<br>30205 - Hematology<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    DNA methylation status of selected genes was correlated with patients' prognosis and mutational status of DNMT3A gene. We found influence of DNA methylation on overall survival and incidence of relapses as well as relationship between DNMT3A mutations and DNA methylation. Further we performed whole genome bisulfite sequencing and expression profiling to reveal the complex role of DNA methylation.

Solution timeline

  • Realization period - beginning

    May 1, 2010

  • Realization period - end

    Nov 30, 2012

  • Project status

    U - Finished project

  • Latest support payment

    Feb 27, 2012

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP13-MSM-OC-U/01:1

  • Data delivery date

    Jun 28, 2013

Finance

  • Total approved costs

    2,400 thou. CZK

  • Public financial support

    2,100 thou. CZK

  • Other public sources

    300 thou. CZK

  • Non public and foreign sources

    0 thou. CZK