Instability of the genome of bone marrow cells of patients with AML and MDS.
Public support
Provider
Ministry of Education, Youth and Sports
Programme
COST
Call for proposals
COST 8 (SMSM2010OC5)
Main participants
—
Contest type
VS - Public tender
Contract ID
1081/2011-320
Alternative language
Project name in Czech
Nestabilita genomu buněk kostní dřeně nemocných s MDS a AML
Annotation in Czech
Zjistit nenáhodnost vstupu chromosomů do přestaveb a rekurenci zlomových míst. Identifikovat geny spolupůsobící při progresi malignity a geny v oblastech s delecemi, zejména na chromosomu 5. Definovat skupiny pacientů vhodné pro individuální léčbu.
Scientific branches
R&D category
AP - Applied research
CEP classification - main branch
EB - Genetics and molecular biology
CEP - secondary branch
FD - Oncology and haematology
CEP - another secondary branch
—
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30204 - Oncology<br>30205 - Hematology
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
By whole-genome analysis we determined the frequency of recurrent unbalanced aberrations in patients with MDS/AML and complex karyotype. We described 375 breakpoints located at known fragile sites as well as atypical 5q deletions that did not include theCDR. We confirmed substantial instability of d chromosome 5, often entering other rearrangements with various partner chromosomes.
Solution timeline
Realization period - beginning
May 1, 2010
Realization period - end
Oct 31, 2012
Project status
U - Finished project
Latest support payment
Feb 27, 2012
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP13-MSM-OC-U/01:1
Data delivery date
Jun 28, 2013
Finance
Total approved costs
2,100 thou. CZK
Public financial support
2,100 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK