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OC10043

Instability of the genome of bone marrow cells of patients with AML and MDS.

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    COST

  • Call for proposals

    COST 8 (SMSM2010OC5)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    1081/2011-320

Alternative language

  • Project name in Czech

    Nestabilita genomu buněk kostní dřeně nemocných s MDS a AML

  • Annotation in Czech

    Zjistit nenáhodnost vstupu chromosomů do přestaveb a rekurenci zlomových míst. Identifikovat geny spolupůsobící při progresi malignity a geny v oblastech s delecemi, zejména na chromosomu 5. Definovat skupiny pacientů vhodné pro individuální léčbu.

Scientific branches

  • R&D category

    AP - Applied research

  • CEP classification - main branch

    EB - Genetics and molecular biology

  • CEP - secondary branch

    FD - Oncology and haematology

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30204 - Oncology<br>30205 - Hematology

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    By whole-genome analysis we determined the frequency of recurrent unbalanced aberrations in patients with MDS/AML and complex karyotype. We described 375 breakpoints located at known fragile sites as well as atypical 5q deletions that did not include theCDR. We confirmed substantial instability of d chromosome 5, often entering other rearrangements with various partner chromosomes.

Solution timeline

  • Realization period - beginning

    May 1, 2010

  • Realization period - end

    Oct 31, 2012

  • Project status

    U - Finished project

  • Latest support payment

    Feb 27, 2012

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP13-MSM-OC-U/01:1

  • Data delivery date

    Jun 28, 2013

Finance

  • Total approved costs

    2,100 thou. CZK

  • Public financial support

    2,100 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK