Indicators II ? reverse detection of received ionizing radiation dose by monitoring of cell population changes using biophysical methods
Project goals
To establish extrapolated calibration curve for determination the recieved dose in individuals exposed to ionizing radiation which could be practical used in the Czech army and to design the best enlistment of this biophysical method into the therapeutic-transfer system of the Czech army.
Keywords
IrradiationMarkers of irradiation of the bloodPeriferaly blood cellsMitochondrial membraneFlow cytometryBiodosimetry
Public support
Provider
Ministry of Defence
Programme
Development - the development of attained operational capabilities of the Czech Armed Forces
Call for proposals
Rozvoj AČR 1 (SMO02008PR980)
Main participants
—
Contest type
VS - Public tender
Contract ID
0801 8 8010 R
Alternative language
Project name in Czech
INDIKÁTORY II - zpětná detekce obdržené dávky ionizujícího záření pomocí monitorování změn buněčných populací biofyzikálními metodami
Annotation in Czech
Získat kalibrační křivku zpětného odečtu obdržené dávky ionizujícího záření použitelnou pro praktické využití AČR a navrhnout nejvhodnějšího zařazení biofyzikální metody zpětného odečtu dávky ionizujícího záření do léčebně-odsunového systému AČR.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FP - Other medical fields
CEP - secondary branch
KA - Militarism
CEP - another secondary branch
—
21100 - Other engineering and technologies
30106 - Anatomy and morphology (plant science to be 1.6)
30107 - Medicinal chemistry
30108 - Toxicology
30109 - Pathology
30221 - Critical care medicine and Emergency medicine
30223 - Anaesthesiology
30224 - Radiology, nuclear medicine and medical imaging
30225 - Allergy
30226 - Rheumatology
30227 - Geriatrics and gerontology
30229 - Integrative and complementary medicine (alternative practice systems)
30230 - Other clinical medicine subjects
30307 - Nursing
30308 - Nutrition, Dietetics
30309 - Tropical medicine
30310 - Parasitology
30311 - Medical ethics
30312 - Substance abuse
30501 - Forensic science
30502 - Other medical science
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Using the multicolor flow cytometry technique we studied the changes mitochondrial membrane potential in dependence on the absorbed dose of irradiation under experimental in vitro and ex vivo conditions in pig. We compared the results with blood human samples irradiated in vitro conditions. We found calibration curve enables the back calculation of obtained dose of irradiation.
Solution timeline
Realization period - beginning
Oct 1, 2008
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Feb 28, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-MO0-OV-U/01:1
Data delivery date
Jul 2, 2012
Finance
Total approved costs
3,608 thou. CZK
Public financial support
2,032 thou. CZK
Other public sources
1,576 thou. CZK
Non public and foreign sources
0 thou. CZK
Basic information
Recognised costs
3 608 CZK thou.
Public support
2 032 CZK thou.
56%
Provider
Ministry of Defence
CEP
FP - Other medical fields
Solution period
01. 10. 2008 - 31. 12. 2011