Determination of important pharmacokinetic and biochemical parameters and evaluation of blood-brain barrier penetration using drugs introduced to Czech Army
Public support
Provider
Ministry of Defence
Programme
Development - the development of attained operational capabilities of the Czech Armed Forces
Call for proposals
Rozvoj AČR 1 (SMO02008PR980)
Main participants
—
Contest type
VS - Public tender
Contract ID
0801 8 8090 R
Alternative language
Project name in Czech
FARMAKO - Stanovení důležitých farmakokinetických a biochemických parametrů a hodnocení průniku do CNS léčiv zavedených do výzbroje AČR
Annotation in Czech
Cílem projektu je definovat farmakokinetiku jednotlivých terapeuticky účinných látek, jejich distribuci v organismu, in vitro a in vivo prostup do centrálního nervového systému a možné následovné poškození mozku, způsobené těmito látkami. Zároveň doplnitstudii o hodnocení důležitých biochemických markerů, jež by mohly být po podání těchto látek ovlivněny.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FP - Other medical fields
CEP - secondary branch
CE - Biochemistry
CEP - another secondary branch
KA - Militarism
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>21100 - Other engineering and technologies<br>30106 - Anatomy and morphology (plant science to be 1.6)<br>30107 - Medicinal chemistry<br>30108 - Toxicology<br>30109 - Pathology<br>30221 - Critical care medicine and Emergency medicine<br>30223 - Anaesthesiology<br>30224 - Radiology, nuclear medicine and medical imaging<br>30225 - Allergy<br>30226 - Rheumatology<br>30227 - Geriatrics and gerontology<br>30229 - Integrative and complementary medicine (alternative practice systems)<br>30230 - Other clinical medicine subjects<br>30307 - Nursing<br>30308 - Nutrition, Dietetics<br>30309 - Tropical medicine<br>30310 - Parasitology<br>30311 - Medical ethics<br>30312 - Substance abuse<br>30501 - Forensic science<br>30502 - Other medical science
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
POV FARMAKO was mainly interested in efficacy and toxicity of commonly used antidotes in Army of the Czech Republic. During this project was established new methods that may be succesfully used in subsequent pharmacokinetics and pharmacodynamics studies.Also new and important information about these therapeutics were included into basic toxicology knowledge.
Solution timeline
Realization period - beginning
Nov 1, 2008
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Feb 28, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-MO0-OV-U/01:1
Data delivery date
Jul 2, 2012
Finance
Total approved costs
1,927 thou. CZK
Public financial support
932 thou. CZK
Other public sources
995 thou. CZK
Non public and foreign sources
0 thou. CZK