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Changes in pharmacokinetics and pharmacodynamics of drugs in the presence of impaired liver function

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    Programme of regional and international cooperation in R&D (National programme of research)

  • Call for proposals

    Regionální a mezinárodní spolupráce ve výzkumu 2 (SMSM2004001P2)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    1074/2005-32

Alternative language

  • Project name in Czech

    Sledování změn farmakokinetiky a farmakodynamiky léčiv při poškozené funkci jater

  • Annotation in Czech

    zavedení vhodné in vitro a in vivo metody pro predikci a hodnocení farmakokinetických a farmakodynamických vlastností látek při jaterním poškození

Scientific branches

  • R&D category

    NV - Nonindustrial research (Applied research excluded Industrial research)

  • CEP classification - main branch

    FR - Pharmacology and apothecary chemistry

  • CEP - secondary branch

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30104 - Pharmacology and pharmacy

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Alterations in transport proteins expression during cholestatsis might produce adaptive changes in pharmacokinetics of drugs-substrates. Decreased biliary secretion may be partly compensated by increased renal elimination

Solution timeline

  • Realization period - beginning

    Jan 1, 2005

  • Realization period - end

    Dec 31, 2008

  • Project status

    U - Finished project

  • Latest support payment

    Feb 21, 2008

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP09-MSM-1P-U/01:1

  • Data delivery date

    Jun 25, 2009

Finance

  • Total approved costs

    2,526 thou. CZK

  • Public financial support

    2,526 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK