Physiologically based prediction of pharmacokinetics prior to in vivo studies: Focus on hepatic and renal drug elimination
Public support
Provider
Ministry of Education, Youth and Sports
Programme
Programme of regional and international cooperation in R&D (National programme of research)
Call for proposals
Regionální a mezinárodní spolupráce ve výzkumu 2 (SMSM2004001P2)
Main participants
—
Contest type
VS - Public tender
Contract ID
1074/2005-32
Alternative language
Project name in Czech
Predikce farmakokinetiky vycházející z fyziologických principů zaměřením na jaterní a ledvinnou eliminaci léčiv
Annotation in Czech
možnosti kombinovaného použití in vitro metod a počítačových modelů in silico pro predikaci farmakokinetiky léčiv in vivo
Scientific branches
R&D category
NV - Nonindustrial research (Applied research excluded Industrial research)
CEP classification - main branch
FR - Pharmacology and apothecary chemistry
CEP - secondary branch
—
CEP - another secondary branch
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OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
30104 - Pharmacology and pharmacy
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
The project was focused on in vitro/in silico based prediction of drug pharmacokinetics. Attention was paid to the contribution of hepatic and renal transporters to drug-drug interactions of amiodarone, corticosteroids and macrolide antibiotics.
Solution timeline
Realization period - beginning
Jan 1, 2005
Realization period - end
Dec 31, 2008
Project status
U - Finished project
Latest support payment
Feb 21, 2008
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP09-MSM-1P-U/01:1
Data delivery date
Jun 25, 2009
Finance
Total approved costs
2,526 thou. CZK
Public financial support
2,526 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK