Development of diagnostic components and adaptable technology of preparation of recombinant vaccines based on capsid nanostructures of the mouse polyomavirus.
Project goals
The objective of this project is development of an adaptable technology for production of recombinant vaccines against infectious diseases of farm and domestic animals. Vaccines against porcine circoviruses and bovine papillomavirus will be created. Fortheir preparation, artificial empty virus capsids (VLPs - virus like particles) and stabile chimeric nanostructures derived from mouse polyomavirus capsids carrying immunogenic epitopes of circovirus 2 Cap protein will be created. Diagnostic components for detection of circovirus and bovinne papillomavirus will also be produced. The project is a joint venture of Faculty of Science, Charles University, Laboratory of Virology and Dyntec spol. s r. o.
Keywords
VLPviral nanoparticlesmouse polyomavirusvaccinesfarm animalsporcine circovirusbovine papillomaviruses
Public support
Provider
Technology Agency of the Czech Republic
Programme
Programme of applied research and experimental development ALFA
Call for proposals
ALFA 3 (STA02013TA03)
Main participants
Univerzita Karlova / Přírodovědecká fakulta
Contest type
VS - Public tender
Contract ID
2013TA03010700
Alternative language
Project name in Czech
Vývoj diagnostických komponent a adaptabilní technologie přípravy rekombinantních vakcín založených na umělých virových nanostrukturách.
Annotation in Czech
Náplní projektu je aplikovaný výzkum a vývoj technologie přípravy rekombinantních vakcín proti infekčním chorobám hospodářských a domácích zvířat, které působí značné hospodářské ztráty. Budou vyvíjeny vakcíny proti prasečím cirkovirům a proti bovinním papilomavirům. K přípravě vakcín budou využity prázdné virové kapsidy (VLPs ? virus-like particles) a stabilní chimerické nanostruktury polyomaviru nesoucí imunogenní epitopy proteinů cirkoviru typu 2, případně dalších patogenů. Dále budou vyvíjeny diagnostické komponenty k identifikaci cirkovirů a bovinních papilomavirů. Na projektu bude spolupracovat firma Dyntec spol. s r.o. a Laboratoř virologie Univerzity Karlovy v Praze, Přírodovědecké fakulty.
Scientific branches
R&D category
AP - Applied research
CEP classification - main branch
GJ - Diseases and animal vermin, veterinary medicine
CEP - secondary branch
EI - Biotechnology and bionics
CEP - another secondary branch
EE - Microbiology, virology
10606 - Microbiology
10607 - Virology
20801 - Environmental biotechnology
20802 - Bioremediation, diagnostic biotechnologies (DNA chips and biosensing devices) in environmental management
20803 - Environmental biotechnology related ethics
20901 - Industrial biotechnology
20902 - Bioprocessing technologies (industrial processes relying on biological agents to drive the process) biocatalysis, fermentation
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
30401 - Health-related biotechnology
30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])
30404 - Biomaterials (as related to medical implants, devices, sensors)
30405 - Medical biotechnology related ethics
40301 - Veterinary science
40401 - Agricultural biotechnology and food biotechnology
40402 - GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming
40403 - Agricultural biotechnology related ethics
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
The project succeeded according to the assignment and the beneficiary demonstrated the knowledge and ability to achieve commercially successful outputs of the project (clinical evaluation and registration) within the description of implementation procedures.
Solution timeline
Realization period - beginning
Jan 1, 2013
Realization period - end
Dec 31, 2016
Project status
U - Finished project
Latest support payment
Feb 17, 2016
Data delivery to CEP
Confidentiality
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.
Data delivery code
CEP17-TA0-TA-U/02:1
Data delivery date
Jul 26, 2017
Finance
Total approved costs
18,614 thou. CZK
Public financial support
12,089 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
6,525 thou. CZK
Recognised costs
18 614 CZK thou.
Public support
12 089 CZK thou.
0%
Provider
Technology Agency of the Czech Republic
CEP
GJ - Diseases and animal vermin, veterinary medicine
Solution period
01. 01. 2013 - 31. 12. 2016