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40 (0,138s) •

Project

New purine nucleoside analogues for therapeutic applications (OC D13.20)

Synthesis of purine nucleosides, heir acyclic analogues and analogues of nucleotides substituted by C=alkyl, aryl and cycloalkyl substituents as purinoceptor modulators.......

CC - Organická chemie

  • 2001 - 2003
    • •
  • 2 662 tis. Kč
    • •
  • 1 335 tis. Kč
    • •
  • MŠMT
Project

New purine nucleoside analogues for therapeutic applications (1P04OCD13.20)

Synthesis of purine nucleosides, heir acyclic analogues and analogues of nucleotides substituted by C=alkyl, aryl and cycloalkyl substituents as purinoceptor modulators.......

FR - Farmakologie a lékárnická chemie

  • 2004 - 2004
    • •
  • 891 tis. Kč
    • •
  • 400 tis. Kč
    • •
  • MŠMT
Project

Immunobiological Activity of Acyclic Nucleotide Analogues (GA307/94/0964)

FR - Farmakologie a lékárnická chemie

  • 1994 - 1996
    • •
  • 1 377 tis. Kč
    • •
  • 2 047 tis. Kč
    • •
  • GA ČR
Project

Novel Cytostatics Based on Acyclic Nucleotide Analogg (GA203/93/0117)

CE - Biochemie

  • 1993 - 1995
    • •
  • 355 tis. Kč
    • •
  • 710 tis. Kč
    • •
  • GA ČR
Project

Novel cytostatics based on acyclic nucleotide analogs Mode of action (IAA455402)

9J - 9

  • 1994 - 1996
    • •
  • 441 tis. Kč
    • •
  • 679 tis. Kč
    • •
  • AV ČR
Project

Acyclic Analogues of Nicotinamide Mononucleotide and Nicotinamide Adenine Dinucleotide as Potential Cytostatics and Antivirals (GA203/93/0118)

9J - 9

  • 1993 - 1995
    • •
  • 700 tis. Kč
    • •
  • 1 400 tis. Kč
    • •
  • GA ČR
Project

Synthesis of base and chein-modified phosphonate analogues of acyclic nucleotides and nicotinamide adenine dinucleotide (IAA455407)

9J - 9

  • 1994 - 1996
    • •
  • 512 tis. Kč
    • •
  • 791 tis. Kč
    • •
  • AV ČR
Project

Synthesis and biological activity study of acyclic adenosine analogues with alfa-branched side chain (GA203/98/P026)

A series of acyclic adenosine analogues with a-branched side chain bearing various functional groups was studied. A new method based on the derivatization of N6-protected adenine derivatives bearing an active methylene group in N7- or N9-pos...

CE - Biochemie

  • 1998 - 1998
    • •
  • 677 tis. Kč
    • •
  • 201 tis. Kč
    • •
  • GA ČR
Project

Syntheses of new prodrug forms of biologically active nucleotide analogues (GA14-00522S)

acyclic nucleoside phosphonates thus far not clinically developed potential of acyclic nucleoside phosphonates as antitumor agents.......

CC - Organická chemie

  • 2014 - 2016
    • •
  • 4 481 tis. Kč
    • •
  • 4 481 tis. Kč
    • •
  • GA ČR
Project

C-alkyl analogues of purines and their biologically active derivatives (GA203/96/0005)

We intend to synthesize novel structural types of purine bases, their acyclic nucleoside analogues and acyclic phosphonate nucleotide analogues of selected types which bear resemblance to the original structures possessing unique th...

CC - Organická chemie

  • 1996 - 1998
    • •
  • 3 399 tis. Kč
    • •
  • 2 784 tis. Kč
    • •
  • GA ČR
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