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656 (0,115s) •

Project

Functional analysis of methyltransferase involved in SL RNA modification in Trypanosoma brucei (GP204/08/P585)

The trypanosomatid SL RNA plays an essential role in trans-splicing and processing of all mRNA. SL RNA provides the m7G-capped SL sequence to the 5'end of every mRNA. The cap structure of the SL RNA is unique in eu...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 035 tis. Kč
    • •
  • 1 035 tis. Kč
    • •
  • GA ČR
Project

Identification of molecular defects caused by mutations in splicing factors linked with retina degeneration (GA23-06129S)

Mutations in several RNA splicing factors affect specific cells in the retina neurons. We will investigate defects in RNA splicing and tissue-specific RNA production and identify genes with aberrant sp...

Cell biology

  • 2023 - 2023
    • •
  • 3 901 tis. Kč
    • •
  • 3 852 tis. Kč
    • •
  • GA ČR
Project

Circular RNAs and their relation to RNA splicing in the pathogenesis of myelodysplastic syndromes (GA20-19162S)

Mutations in RNA splicing factors represent the most common molecular of their roles in MDS pathogenesis, the impact of mutated splicing factors on circular RNAs (circRNAs) has not been studied. CircRNAs constitute...

Human genetics

  • 2020 - 2023
    • •
  • 9 979 tis. Kč
    • •
  • 9 687 tis. Kč
    • •
  • GA ČR
Project

Identification and characterization of a new pathway regulating pre-mRNA splicing (GX23-04754X)

and splicing. RNA polymerase II transcribes protein-coding genes and produces pre-mRNAs RNA-protein complex. Spliceosome activation is a major, but poorly characterized of transcription to the regulation of splicing

Biochemistry and molecular biology

  • 2023 - 2027
    • •
  • 49 981 tis. Kč
    • •
  • 49 981 tis. Kč
    • •
  • GA ČR
Project

Molecular characterization of retinal and cerebellar defects caused by mutations in splicing factor Prpf8 (GA20-04099S)

transcriptome analyses with iCLIP approach to identify RNA splicing perturbations induced that flawed RNA splicing compromises cilia structure as a common feature of observedMutations in splicing factors ...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 10 124 tis. Kč
    • •
  • 10 124 tis. Kč
    • •
  • GA ČR
Project

Characterising the regulatory mechanisms at decoy 5’ splice sites (GF24-11219K)

In the last few years, it has been shown that cryptic splice sites can play an important role in regulating RNA splicing and thus gene expression. Many such cryptic we will focus on decoy 5’ splice sites (d-5’ss), ...

Genetics and heredity (medical genetics to be 3)

  • 2024 - 2027
    • •
  • 8 364 tis. Kč
    • •
  • 8 329 tis. Kč
    • •
  • GA ČR
Project

Classification of variants of unknown significance in cancer susceptibility genes by the multiplex PCR/NGS-based analysis of their impact on pre-mRNA splicing (II) (NU23-03-00150)

. The project aims to implement targeted NGS analyses of RNA samples in case of diagnostic confusion in the clinical interpretation of VUS with possible impact on mRNA splicing affecting the mRNA splicing in cancer suscepti...

Human genetics

  • 2023 - 2026
    • •
  • 10 613 tis. Kč
    • •
  • 10 613 tis. Kč
    • •
  • MZ
Project

Structural basis of aberrant splicing in cystic fibrosis (GA15-21122S)

Alternative splicing of pre-mRNAs is tightly regulated and any imbalance can change the outcome of gene expression which often leads to disease. Despite the importance of alternative splicing regulation our knowledge at the molecula...

CE - Biochemie

  • 2015 - 2019
    • •
  • 8 288 tis. Kč
    • •
  • 8 288 tis. Kč
    • •
  • GA ČR
Project

Regulation of alternative splicing via chromatin acetylation (GAP305/10/0424)

Alternative splicing (AS) is one of the key steps in gene expression that greatly increases coding potential of our genome. Splicing is regulated by numerous splicing regulators and target pre-mRNAs. In this project, we pro...

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 4 813 tis. Kč
    • •
  • 4 813 tis. Kč
    • •
  • GA ČR
Project

Centre for RNA Biology (GBP305/12/G034)

The world of RNA expands from nucleus, where its various forms are synthesized and specifically modified, into cytoplasm, where RNA serves as a template for timely as a subject for programmed degradation. Hence it is evident that

EB - Genetika a molekulární biologie

  • 2012 - 2018
    • •
  • 87 942 tis. Kč
    • •
  • 87 942 tis. Kč
    • •
  • GA ČR
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