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359 (0,289s) •

Project

Inhibition of hepatocellular carcinoma progression (7AMB12AT011)

in hepatocellular carcinoma. The Czech group developed highly active CDK inhibitors to preclinically test the CDK inhibitors for activities against liver carcinoma. We expect......

CE - Biochemie

  • 2012 - 2013
    • •
  • 139 tis. Kč
    • •
  • 139 tis. Kč
    • •
  • MŠMT
Project

Targeting mechanical properties and mechanotransduction in hepatocellular carcinoma (GA21-21736S)

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver. HCC is a heterogeneous tumor with high metastatic potential and complex pathophysiology. There is increasing evidence that tissue mechanics plays critical role in ...

Cell biology

  • 2021 - 2023
    • •
  • 7 692 tis. Kč
    • •
  • 7 692 tis. Kč
    • •
  • GA ČR
Project

Early diagnostics of hepatocellular carcinoma in patients with liver cirrhosis by novel molecular spectrometric biomarkers in blood plasma (NV19-08-00525)

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, the development of which is linked to liver cirrhosis. The only way to improve the very poor prognosis of HCC is an early diagnosis. The current surv...

Analytical chemistry

  • 2019 - 2023
    • •
  • 12 461 tis. Kč
    • •
  • 12 461 tis. Kč
    • •
  • MZ
Project

The Impact of Liver-specific Plectin Deficiency on Pathogenesis of Liver Diseases (GA15-23858S)

acid and plectin-controlled integrin signaling pathways. Using hepatocellular carcinoma cells we will dissect isoform-specific role of plectin in motility......

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 5 924 tis. Kč
    • •
  • 5 924 tis. Kč
    • •
  • GA ČR
Project

Epigenetics approaches in hepatocellular carcinoma (NV18-03-00058)

Liver diseases are a tremendous health burden worldwide. Obesity, in addition to alcohol and viral hepatitis, are major risks for liver disease, the pathological endpoint of which is the devastating hepatocellular carcinoma (HCC), w...

Endocrinology and metabolism (including diabetes, hormones)

  • 2018 - 2021
    • •
  • 8 612 tis. Kč
    • •
  • 8 612 tis. Kč
    • •
  • MZ
Project

Expression of biotransformation enzymes in primary liver cancers (NV17-28231A)

The project proposed aims at studying expression of biotransformation enzymes in primary liver cancer, namely hepatocellular carcinoma (HCC). Hepatocytes constitute approx. 80% of liver cell population and form a major biotransforma...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2021
    • •
  • 14 965 tis. Kč
    • •
  • 14 565 tis. Kč
    • •
  • MZ
Project

Novel cancer diagnostics based on glycogen as body´s own nanosized carrier (NV15-25781A)

in hepatocellular carcinomas or based on muscarinic and benzodiazepine receptor ligands...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2018
    • •
  • 11 525 tis. Kč
    • •
  • 10 601 tis. Kč
    • •
  • MZ
Project

Influence of glycosylation on haptoglobin structure in patients with liver diseases. (LH13051)

Monitoring changes in haptoglobin three dimensional structure under the influence of altered glycosylation in patients with hepatocellular carcinoma and cirrhosis. Developing and optimizing methods for chemical cross-linking and H/D...

CE - Biochemie

  • 2013 - 2015
    • •
  • 1 575 tis. Kč
    • •
  • 1 575 tis. Kč
    • •
  • MŠMT
Project

Detailed analysis of specificity, heterogeneity and role of anti-calreticulin antibodies in oncological and autoimmune diseases. (GA13-14608S)

using ELISA with human recombinant CRT as an antigen in patients with hepatocellular carcinoma, secondary liver tumors, gall-bladder and pancreatic adenocarcinoma, cholangiogenic carcinoma, breast carcinoma, prima...

FE - Ostatní obory vnitřního lékařství

  • 2013 - 2019
    • •
  • 3 526 tis. Kč
    • •
  • 3 526 tis. Kč
    • •
  • GA ČR
Project

Fuctional diversity of hepatitis C virus quasispecies evaluated by high-throughput analysis of IRES elements activities - implications for the therapy (GA301/07/0607)

which can further develop to liver cirrhosis and hepatocellular carcinoma. Hepatitis...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 5 344 tis. Kč
    • •
  • 5 344 tis. Kč
    • •
  • GA ČR
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