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51 (0,149s) •

Project

Regulation of the embryonic stem cell pluripotency factor Oct4 via guanine quadruplex in its promoter (GP14-33947P)

are unusually guanine rich and, thus, may potentially form guanine quadruplexes. These sites is the quadruplex involved in the regulation of the Oct4 and, in fact, in an origin DNA-binding domains of the SAF-A pro...

BO - Biofyzika

  • 2014 - 2016
    • •
  • 1 505 tis. Kč
    • •
  • 1 505 tis. Kč
    • •
  • GA ČR
Project

Biophysical characterization of guanine quadruplexes in the RNA genome of tick-borne encephalitis virus and elucidating their role in viral life cycle (GA20-20229S)

Guanine quadruplexes (G4) represent structurally diverse group of unusual of their cellular roles was reported. RNA quadruplexes are very stable, even in comparison techniques, characterize quadruplexes in the TBEV...

Biophysics

  • 2020 - 2023
    • •
  • 10 753 tis. Kč
    • •
  • 10 753 tis. Kč
    • •
  • GA ČR
Project

The fascinating physical chemistry of DNA studied by advanced computations (GA21-23718S)

methods. The studied topics will include basic folding principles of guanine quadruplexes, short guanine-rich hairpins and i-DNA, sequence-dependent ability of Holliday junctions to form crystal lattices, binding and react...

Physical chemistry

  • 2021 - 2024
    • •
  • 5 874 tis. Kč
    • •
  • 5 874 tis. Kč
    • •
  • GA ČR
Project

Role of guanine quadruplexes in chromatin architecture mediated by CTCF protein (GA22-29738S)

of potential quadruplex-forming sites (G4). G4 are secondary structures of nucleic acids, based on pairing of four guanine residues through Hoogsteen hydrogen bonds. G4......

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 4 889 tis. Kč
    • •
  • 4 889 tis. Kč
    • •
  • GA ČR
Project

Guanine quadruplex-mediated functions of p53, p63 and p73 proteins in cancer biology (GA19-15168S)

G-quadruplexes, non-B DNA structures, are linked to regulation of transcription, replication and genome stability. In the previous project, we showed that G-quadruplexes project is designed to prove G-quadruplexes as regula...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 3 782 tis. Kč
    • •
  • 3 776 tis. Kč
    • •
  • GA ČR
Project

Tetrastranded arrangements of DNA and their interactions (GA19-17063S)

Tetra-stranded structures of nucleic acids, namely guanine quadruplexes and cytosine i-motifs, are, due to their numerous regulatory functions in vivo, in the spotlight of the current molecular biology. Our observations indicate, in...

Biophysics

  • 2019 - 2022
    • •
  • 5 702 tis. Kč
    • •
  • 5 681 tis. Kč
    • •
  • GA ČR
Project

Multi-scale modeling of structure, dynamics and folding of DNA. (GA16-13721S)

development and testing. The main topics include studies of a diverse set of guanine quadruplexes, with special emphasis given to the atomistic picture of their folding......

CF - Fyzikální chemie a teoretická chemie

  • 2016 - 2018
    • •
  • 4 284 tis. Kč
    • •
  • 3 921 tis. Kč
    • •
  • GA ČR
Project

Identification and biophysical characterization of regulatory DNA elements of the gene for main pluripotency factor POU5F1 (GJ17-19170Y)

Pou5f1 gene is the key regulator of cellular pluripotency thus it has to be tightly regulated. In the previous project we identified guanine quadruplex in close proximity of the pou5f1 transcription start and we showed the quadr...

BO - Biofyzika

  • 2017 - 2019
    • •
  • 3 679 tis. Kč
    • •
  • 3 553 tis. Kč
    • •
  • GA ČR
Project

DNA structure in solution and at electrode surfaces electrochemical methods as potent tools for the analysis of DNA structure and interactions. (GA16-01625S)

of alternative DNA structures, such as non-canonical DNA duplexes, guanine and cytosine quadruplexes. We will use earlier described structural transitions of specific nucleotide......

CG - Elektrochemie

  • 2016 - 2019
    • •
  • 4 476 tis. Kč
    • •
  • 4 281 tis. Kč
    • •
  • GA ČR
Project

Nucleic Acid Regulatory Sequences - polymorphism, dynamics, and interactions (GA15-06785S)

The project is aimed at detail investigation of structural arrangement, formation of biologically relevant complexes, and dynamics of selected representative types of nucleic acid regulatory sequences - DNA guanine quadruplexes, miR...

BO - Biofyzika

  • 2015 - 2017
    • •
  • 11 631 tis. Kč
    • •
  • 11 631 tis. Kč
    • •
  • GA ČR
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