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46 (0,083s) •

Project

Elucidation of the mechanism of flavonoid-dependent cardioprotection and changes in the bioenergetic status of the cell (GAP301/11/0662)

cytoprotective activity and have been linked to cardioprotection. Mitochondria are central players in the pathophysiology of cardioprotection, but the link between flavonoid executing their cardioprotective ability unlike ...

CE - Biochemie

  • 2011 - 2014
    • •
  • 6 595 tis. Kč
    • •
  • 6 595 tis. Kč
    • •
  • GA ČR
Project

Selective COX-1 inhibition as cardioprotective therapeutical target (LTC18065)

Project is aimed to synthesis, optimization and evaluation of natural products and their derivatives with potential cardioprotective effects. We will focus on therapeutic options of selective cyclooxygenase-1 inhibitors, optionally with seco...

Organic chemistry

  • 2018 - 2021
    • •
  • 4 086 tis. Kč
    • •
  • 4 086 tis. Kč
    • •
  • MŠMT
Project

Myocardial damage induced by anticancer drugs and ischemia-reperfusion new possibilities of pharmacological cardioprotection. (GA305/09/0416)

of freeiron. This implies the utility of iron chelation as effective cardioprotective of pharmacodynamics of cardioprotective effects of DEX against I/R injury and ANT cardiotoxicity structure modification with aim to improve its <...

FR - Farmakologie a lékárnická chemie

  • 2009 - 2012
    • •
  • 6 276 tis. Kč
    • •
  • 6 276 tis. Kč
    • •
  • GA ČR
Project

Cardioprotective potential of cold acclimation in rats the role of uncoupling proteins. (GA17-07748S)

preoccupied solely with severe cold stress and cardioprotective effects of cold adaptation mechanisms of endogenous cardioprotection using a model of rat exposed to 5-week......

ED - Fyziologie

  • 2017 - 2021
    • •
  • 6 531 tis. Kč
    • •
  • 6 186 tis. Kč
    • •
  • GA ČR
Project

Comprehensive cardioprotection in acute myocardial infarction (IZ2011)

9F - 9

  • 1994 - 1995
    • •
  • 225 tis. Kč
    • •
  • 450 tis. Kč
    • •
  • MZ
Project

Molecular mechanisms of adverse and protective effects of morphine and methadone on the rat heart (IAA501110901)

cardioprotective or adverse effects of these drugs. We shall analyze the cellular of cardioprotection. Better understanding of this phenomenon is useful for future pharmacological......

ED - Fyziologie

  • 2009 - 2013
    • •
  • 7 683 tis. Kč
    • •
  • 7 683 tis. Kč
    • •
  • AV ČR
Project

The role of lipids in the regulation of mitochondria-dependent cardioprotection. (ME09018)

In this project we propose to study primary unanswered questions which deal with the role of lipids in mitochondria-dependent cardioprotection. We will test the hypothesis that fatty acids and products of lipid peroxidation and nitration reg...

ED - Fyziologie

  • 2009 - 2012
    • •
  • 2 400 tis. Kč
    • •
  • 2 400 tis. Kč
    • •
  • MŠMT
Project

Realising the therapeutic potential of novel cardioprotective therapies (LTC18041)

will be evaluated with regard to applicability in cardioprotective and heart failure therapy....

Biochemistry and molecular biology

  • 2018 - 2021
    • •
  • 3 997 tis. Kč
    • •
  • 3 997 tis. Kč
    • •
  • MŠMT
Project

New potential cardioprotective agents study of structure-activity relationships in various types of myocardial injury (GA13-15008S)

preclinical evaluations of novel potential cardioprotective agents - analogs on metabolism and other pharmacokinetic properties determining effective cardioprotection......

FR - Farmakologie a lékárnická chemie

  • 2013 - 2017
    • •
  • 10 985 tis. Kč
    • •
  • 10 985 tis. Kč
    • •
  • GA ČR
Project

Modern bioanalytical contribution to the interdisciplinary investigation of bisdioxopiperazine cardioprotective agents. (GPP206/10/P439)

in the myocardium and shad more light on its mechanism of cardioprotective action. Hence of cardioprotection....

CB - Analytická chemie, separace

  • 2010 - 2012
    • •
  • 838 tis. Kč
    • •
  • 838 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 46