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10 (0,089s) •

Project

Retention mechanisms of intact glycopeptides in hydrophilic interaction liquid chromatography (GJ19-18005Y)

of glycopeptides in hydrophilic interaction liquid chromatography (HILIC). Accordingly, we a practical guide for selecting suitable conditions for glycopeptide separation by HILIC. Moreover, we will derive a mathematical model for ...

Analytical chemistry

  • 2019 - 2022
    • •
  • 3 402 tis. Kč
    • •
  • 3 402 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of emergence and spread of glycopeptide resistance in Staphylococcus haemolyticus (NV15-28807A)

Staphylococcus haemolyticus is one of the most multidrug-resistant species associated with nosocomial infections. Glycopeptides (GP) are among few antibiotic is alarming. In order to prevent a decline of glycopeptide activity again...

EE - Mikrobiologie, virologie

  • 2015 - 2018
    • •
  • 7 182 tis. Kč
    • •
  • 6 746 tis. Kč
    • •
  • MZ
Project

Glycan-dependent regulation of NK cell recognition structural biology and novel methods of glycopeptide analysis (LTC20078)

mechanisms of glycopeptides will be conducted and used to optimize mass spectrometry identification of isobaric glycopeptides of model and clinical samples.......

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 3 998 tis. Kč
    • •
  • 3 998 tis. Kč
    • •
  • MŠMT
Project

Synthetic multiple antigenic glycopeptides (MAG) containing mucine antigenic determinants - potential diagnostics and cancer vaccines. (GA303/01/0690)

Cancer associated antigen of the mucin type play key-role in the tumour diagnostics. One of the most important glycoprotein structures of this type is MUC-1. This structure contains T, Tn and sialosyl-Tn tumour antigens. In the framework of this proj...

EC - Imunologie

  • 2001 - 2003
    • •
  • 4 134 tis. Kč
    • •
  • 3 208 tis. Kč
    • •
  • GA ČR
Project

Development of Lanthanide Raman Probes for Biomedical Analyses and Imaging (GJ19-05974Y)

of a broad range of biomolecules and in living cells. Model glycopeptides and several by theoretical calculations will be used to monitor the interaction between glycopeptides......

Biophysics

  • 2019 - 2022
    • •
  • 5 988 tis. Kč
    • •
  • 5 988 tis. Kč
    • •
  • GA ČR
Project

Stepwise synthesis of oligosaccharides of 2-amino-2-deoxy sugars and preparation of their biologically important conjugates (GA203/96/0309)

of glycopeptides with immunostimulating, antiviral, antitumour, and radioprotective activity....

CC - Organická chemie

  • 1996 - 1998
    • •
  • 1 360 tis. Kč
    • •
  • 900 tis. Kč
    • •
  • GA ČR
Project

Preparation and study of biologically active biopolymers and selected model-compounds (VS96140)

One of the most rapidly advancing area of the biomedicinal research deals with study of relationship between chemical structure and biological activity. This research is currently facilitated by methods of modern structural analysis , mainly NMR and ...

CC - Organická chemie

  • 1996 - 2000
    • •
  • 24 051 tis. Kč
    • •
  • 14 438 tis. Kč
    • •
  • MŠMT
Project

Calixarene-based multivalent glyco-druge - design, structure, biological (antitumor and antiviral) activity (IAA400200503)

New water soluble ligands will be designed. The calix[n]arene scaffold in different (semi)rigid conformations, and saccharides, glycopeptides, glykosaminoacids and glycodendrons will be used as biomolecules. Computation methods (mol. dynamic...

CC - Organická chemie

  • 2005 - 2009
    • •
  • 5 028 tis. Kč
    • •
  • 5 028 tis. Kč
    • •
  • AV ČR
Project

Solid phase synthesis of glycopeptide denrimers with T and TN antigenic structures and their biological activities (GA203/97/0176)

Tumour associated antigens of Tn and T type bound to branched oligolysine core (Multiple Antigenic Peptide, MAP) will be prepared by solid phase methodology. We intend to use three types of carriers: Sieber amide resin, biocompatible Tenta Gel S NH2 ...

CC - Organická chemie

  • 1997 - 1999
    • •
  • 3 418 tis. Kč
    • •
  • 2 524 tis. Kč
    • •
  • GA ČR
Project

Experimental development of new antibacterial compounds and assessment of their potential towards combination therapy (NU21-05-00482)

Bacterial infections are a problem that threatens the health of both individuals and whole society, even in economically developed countries. Many staphylococci (methicillin-resistant S. aureus, or coagulase-negative staphylococci resistant to gl...

Medicinal chemistry

  • 2021 - 2024
    • •
  • 8 073 tis. Kč
    • •
  • 8 073 tis. Kč
    • •
  • MZ
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