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591 (0,074s) •

Project

Evaluation of dentritic cells administration in multiple myeloma. (NC6152)

Due to the short event-free survival and poor prognosis of patients in relapsing MM despite the use of myeloablative therapy we will try to improve their prognosis by using administration of dendritic cells primed with specific anti...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 1 054 tis. Kč
    • •
  • 1 054 tis. Kč
    • •
  • MZ
Project

Molecular-cytogenetic analysis of marked plasma cells and prognostic significance of clonal chromosomal aberrations in multiple myeloma (NR8183)

Detection of selected clonal chromosomal aberrations in immunofluorescence-marked plasma cells in patients with multiple myeloma using molecular cytogenetic methods. Evaluation of the impact of selected chromosomal abnormalities on the p...

FD - Onkologie a hematologie

  • 2004 - 2007
    • •
  • 3 329 tis. Kč
    • •
  • 3 091 tis. Kč
    • •
  • MZ
Project

Assessment of free light chains as auxiliary marker for the evaluation of prognosis and of the response to treatment in patients with multiple myeloma and with monoclonal gammopathy of unknown (NS10387)

Development possibilities of new methods for FLC assay ? measurement optimization via ELISA instruments and comparison with the current method. Determination of FLC as a marker of the stringent CR in multiple myeloma, realization of the sCR ...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 6 311 tis. Kč
    • •
  • 6 311 tis. Kč
    • •
  • MZ
Project

Significance of 18F-FDG PET/CT, whole body MRI and 99mTc-MIBI scintigraphy in diagnosis, clinical staging and monitoring of course of multiple myeloma (NR9489)

, assessment of the degree, location and activity of multiple myeloma (MM). Comparison prognosticfactors, IPI and SWOG staging systems and perspectivelly directly with prognosis of MM, evaluation of the degree, activity and therapy ...

FD - Onkologie a hematologie

  • 2007 - 2010
    • •
  • 2 915 tis. Kč
    • •
  • 2 812 tis. Kč
    • •
  • MZ
Project

Angiogenesis, angiogenic cytokines and indices of plasma cell kinetics in multiple myeloma clinical and prognostic significance (NC7503)

Assessment of the relation of the angiogenesis density to the parametrs of kinetics of myeloma cells ( propidium iodide index/CD138 and markers of apoptosis -annexin V-FITC, PARP, caspase 3 and 8, p53 and Bcl-2) and cyclin D1. Comparison for...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 2 338 tis. Kč
    • •
  • 2 305 tis. Kč
    • •
  • MZ
Project

Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma (NT13190)

This study is focused on detailed characterization of MM patients based on expression profile of genes known to be involved in regulating centrosome duplication and function with known role in oncogenesis. Based on our previous results, we anticipate...

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 8 515 tis. Kč
    • •
  • 8 515 tis. Kč
    • •
  • MZ
Project

Optimizing targets and therapeutics in high risk and refractory multiple myeloma (7E12070)

Multiple myeloma (MM) is an incurable disease with rapidly growing prevalence and poor prognosis. Consequently, it is the goal of OPTATIO consortium to seek out novel strategies for the development of novel diagnostic and therapeuti...

FD - Onkologie a hematologie

  • 2012 - 2014
    • •
  • 2 334 tis. Kč
    • •
  • 2 334 tis. Kč
    • •
  • MŠMT
Project

Clinical implication of circulating miRNA in monoclonal gammopathies (NT14575)

Based on analysis of global profiles of expression of serum miRNA, we want to create a new prognostic panel allowing for stratification of patients with monoclonal gammopathies according to individual risk of disease progression to multiple myelo...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 141 tis. Kč
    • •
  • 7 141 tis. Kč
    • •
  • MZ
Project

Diagnostics of minimal residual disease of multiple myeloma using selective isolation of monoclonal antibodies and free light chains from blood (NW24-03-00347)

Multiple myeloma (MM) is the second most common hematologic malignancy with prognosis calculated from a few months to several decades. Since the prognosis of MM is highly associated with the depth of response to treatment, ...

Hematology

  • 2024 - 2027
    • •
  • 8 692 tis. Kč
    • •
  • 8 692 tis. Kč
    • •
  • MZ
Project

Evaluation of Cellular Immunity and Molecular Analysis of Myeloma-Specific T cells in Patients with Multiple Myeloma (NC7475)

The aim of this study is to identify and characterize myeloma-specific T cells in patients with multiple myeloma. Immunocompetent cells will be evaluated before, during and after immunotherapy in patients with multiple myeloma

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 2 498 tis. Kč
    • •
  • 2 404 tis. Kč
    • •
  • MZ
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