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1 380 (0,297s) •

Project

Vývoj metod pro studium struktury farmakologicky aktivních enzymů (8X17050)

. X-ray crystallography provides details of interatomic interactions necessary (Slovakia) and X-ray diffraction (Czech Republic) to accomplish our scientific goals-ray crystallography. S...

BO - Biofyzika

  • 2017 - 2018
    • •
  • 110 tis. Kč
    • •
  • 110 tis. Kč
    • •
  • MŠMT
Project

Structural biology using new generation X-ray sources (8J23FR035)

for new powerful X-ray sources. This will enable the Prague laboratory to expand and transform projects beyond classical "static" crystallography. It will open up a unique opportunity to get a practical insight into serial...

Biophysics

  • 2023 - 2024
    • •
  • 156 tis. Kč
    • •
  • 156 tis. Kč
    • •
  • MŠMT
Project

Development of macromolecular x-ray crystallography and computer-aided modelling for genetic engineering and drug design in the Czech and Slovak Republics (OK 169)

BO - Biofyzika

  • 1996 - 1997
    • •
  • 613 tis. Kč
    • •
  • 208 tis. Kč
    • •
  • MŠMT
Project

Enzyme hydration and flexibility studied by advanced structural and biophysical methods (GA17-24321S)

access tunnels and closely related luciferase RLuc will be investigated by X-ray and neutron crystallography, time-resolved crystallography and hydrogen-deuterium exchange......

CE - Biochemie

  • 2017 - 2019
    • •
  • 9 834 tis. Kč
    • •
  • 9 578 tis. Kč
    • •
  • GA ČR
Project

Automac interpretation of electron density maps for structure genomics (GA204/06/1007)

The aim of this project is development of an automatic expert system and a computer program for electron density map interpretation and for automatic model building in the protein and nucleic acids crystallography. Such a system is needed fo...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 695 tis. Kč
    • •
  • 695 tis. Kč
    • •
  • GA ČR
Project

Laboratory of Structure and Dynamics of Biomolecules (VS96095)

) willefficiently be used. The project is a combination of NMR spectroscopy, X-ray crystallography and computer modeling. The scientific goals include both methodoly development......

CC - Organická chemie

  • 1996 - 2000
    • •
  • 27 940 tis. Kč
    • •
  • 19 544 tis. Kč
    • •
  • MŠMT
Project

Conformational dynamics of nucleic acids (GA203/05/0388)

. Biologicaly relevant structural motifs will be extracted from X-ray crystallography data methodscombined with X-ray and NMR analyses. The aim is to substantially improve the quality......

CF - Fyzikální chemie a teoretická chemie

  • 2005 - 2007
    • •
  • 4 707 tis. Kč
    • •
  • 4 707 tis. Kč
    • •
  • GA ČR
Project

NECESSITY – New chemical entities for modulating SARS-CoV2 activity (GF21-39625L)

not existing in commercial libraries by high-throughput X-ray crystallography followed...

Medicinal chemistry

  • 2021 - 2024
    • •
  • 4 973 tis. Kč
    • •
  • 4 973 tis. Kč
    • •
  • GA ČR
Project

NMR crystallography of active pharmaceuticals ingredients for industrial applications (2B08021)

The main target of the proposed project is the development of the new analytical techniques of NMR crystallography leading to the control of pharmaceuticals manufacture, unambiguous identification of polymorphic impurities, and detail descri...

CB - Analytická chemie, separace

  • 2008 - 2011
    • •
  • 12 123 tis. Kč
    • •
  • 10 523 tis. Kč
    • •
  • MŠMT
Project

Development of non-canonical inhibitors of glutamate carboxypeptidase II structure-activity relationship studies and biological activity (GJ19-22269Y)

the inhibitory data with X-ray crystallography. Lead candidates will be evaluated in vivo...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 6 617 tis. Kč
    • •
  • 6 617 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 1 380