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894 (0,081s) •

Project

Functional analysis of candidate components of the RNA editing machinery in the flagellate Trypanosoma brucei (IAA5022302)

, and thus represent promising pharmacological targets. We want to prepare, using RNA interference, inducible knock-out cells lines for guide RNA binding proteins 21 and 25, RNA helicase, and RNA ligase. A...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 2 248 tis. Kč
    • •
  • 1 838 tis. Kč
    • •
  • AV ČR
Project

Application of MicroRNAs and Small Interfering RNAs in Diagnostics and Treatment of Leukemia (NR9293)

MicroRNAs and small interfering RNAs (siRNA) function as sequence-specific modulators of a gene expression. Regulation of the gene expression using small RNAs, called RNA interference, has a crucial role in tumor f...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 3 593 tis. Kč
    • •
  • 3 593 tis. Kč
    • •
  • MZ
Project

Targeted gene silencing in tomato plants using RNA interference against quarantine pathogen Tobacco Ringsot Virus (TRSV) (LTC18001)

The aim of this project is to apply intron-spliced hairpin RNA silencing-based technologies to induce virus resistance in tomato plants against Tomato Ringspot virus (TRSV). Recombinant ihpRNA plasmid containing TRSV capsid protein will be g...

GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming

  • 2018 - 2020
    • •
  • 2 604 tis. Kč
    • •
  • 2 604 tis. Kč
    • •
  • MŠMT
Project

RNA interference applications in chickens (GA523/04/0569)

We plan to use the recently described phenomenon of RNA interference (RNAi) in the chicken model. First, we would like to establish replication-competent retroviral RNAs into chicken embryos and developmental effects of the...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2004 - 2006
    • •
  • 3 153 tis. Kč
    • •
  • 3 153 tis. Kč
    • •
  • GA ČR
Project

Identification of tick salivary molecules facilitating transmission of Borrelia burgdorferi using RNA interference (IAA600960811)

is to identify SAT moleculesby gene silencing using RNA interference. Genes coding...

EC - Imunologie

  • 2008 - 2010
    • •
  • 3 228 tis. Kč
    • •
  • 3 228 tis. Kč
    • •
  • AV ČR
Project

The inhibition of tissue factor expression by cells of isolated pancreatic islets using RNA interference (GP303/09/P200)

are not efficient enough. Recently discovered technique of RNA interference made possible was not reported yet. Whether inhibition of tissue factor by RNA interference will be safe......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2009 - 2011
    • •
  • 1 837 tis. Kč
    • •
  • 1 837 tis. Kč
    • •
  • GA ČR
Project

Hybrid gene TEL/AML1 and Asparagine Synthetase gene in pathogenesis of childhood leukemias. (NE7433)

Proposed study will concentrate on relationship between TEL/AML1 hybrid gene, L-Asparaginase and Asparagine Synthetase regulation in leukaemic cells. We will employ modern approaches including quantitative real-time PCR and RNA interfere...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 3 299 tis. Kč
    • •
  • 3 284 tis. Kč
    • •
  • MZ
Project

Flax seed for human health (2B06087)

with the RNA interference transgene technology using. High-oleic genotype exploitable...

EB - Genetika a molekulární biologie

  • 2006 - 2011
    • •
  • 14 039 tis. Kč
    • •
  • 12 581 tis. Kč
    • •
  • MŠMT
Project

A Reverse Genetic Approach to Study Steroid Response in Lepidopteran Insects (IAB5007002)

pathway in lepidopteran insects using the innovative reverse genetic approach of RNA-mediated interference. These experiments should ascertain the epistasis among genes discriminante between nuclear receptor isoforms. Role of a nat...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 2 056 tis. Kč
    • •
  • 1 120 tis. Kč
    • •
  • AV ČR
Project

Study of the oncogenic properties of the Kaposi's sarcoma-associated herpesvirus-encoded vIRF-3 using the method of RNA interference (RNAi) (GA204/09/0773)

the method of RNA interference, we aim to generate the KSHV-positive cell lines...

EE - Mikrobiologie, virologie

  • 2009 - 2013
    • •
  • 8 142 tis. Kč
    • •
  • 8 142 tis. Kč
    • •
  • GA ČR
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