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1 709 (0,357s) •

Project

Targeted inhibition of BCL2 family proteins in experimental therapy of diffuse large B-cell lymphoma (DLBCL) (NV15-27757A)

Diffuse large B-cell lymphoma (DLBCL) represents the most prevalent type of non with poor prognosis in DLBCL. MCL1 was recently reported overexpressed in part of DLBCL clinically in diverse B-cell malignan...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 6 991 tis. Kč
    • •
  • 6 991 tis. Kč
    • •
  • MZ
Project

Molecular Aspects of B-cell Receptor Signal Initiation as Targets for Specific Therapy of non-Hodgkin Lymphoma. (NV18-03-00117)

chemotherapy combination over 40 years old. The B-cell receptor (BCR) inhibition is such emerging therapy applicable to various B-cell derived NHL, which were shown to use) and “tonic” (analogous to baseline BCR signaling in restin...

Oncology

  • 2018 - 2022
    • •
  • 11 156 tis. Kč
    • •
  • 11 156 tis. Kč
    • •
  • MZ
Project

Identification of novel risk factors and molecular mechanisms of central nervous system relapse in diffuse large B-cell lymphoma (NU23-03-00127)

Central nervous system (CNS) relapse in diffuse large B-cell lymphoma (DLBCL relapse in DLBCL and to guide which patients should be treated with additional index for CNS relapse prediction in DLBCL (Aim 1). Next, w...

Hematology

  • 2023 - 2026
    • •
  • 14 404 tis. Kč
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  • 14 404 tis. Kč
    • •
  • MZ
Project

Advanced molecular testing for aggregate diagnosis and management of DLBCL patients engagement of gene expression profiling, liquid biopsy and long-read sequencing (NU22-08-00227)

Diffuse large B-cell lymphoma (DLBCL) is the most common adult type of non objectives in DLBCL clinically orientated research. In the proposed project, we aim as an alternative or accompanying technologies to standard exami...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2022 - 2025
    • •
  • 12 741 tis. Kč
    • •
  • 12 741 tis. Kč
    • •
  • MZ
Project

The role of microbiome in pathogenesis of intraocular, systemic and central nervous system lymphoma (NU20-03-00253)

Microenvironment plays a significant role in the lymphoma pathogenesis and prognosis. Since there is such a close interaction between the immune system and the intestinal microbiota, it is not surprising that some lymphomas such as mucosa-associated ...

General and internal medicine

  • 2020 - 2023
    • •
  • 17 369 tis. Kč
    • •
  • 17 369 tis. Kč
    • •
  • MZ
Project

Early identification of prognostic factors connected with worse outcome of Non-Hodgkin’s Lymphoma (NU21-03-00411)

represent the urgent unmet medical need. The project is focused on DLBCL and FL in correlation with clinical and histological features. All together 200 DLBCL and 100 FL to DLBCL detection (100 R/R FL patients will be incl...

Oncology

  • 2021 - 2025
    • •
  • 16 976 tis. Kč
    • •
  • 16 888 tis. Kč
    • •
  • MZ
Project

Correlation of molecular biological, immunohistochemical and clinical characteristics of diffuse large B cell lymphoma in terms of diagnostical and prognostic algorithm. (NS9791)

Retrospectively, the expression of selected genes in patients with DLBCL will be studied from FFPE (formalin fixed, paraffin embedded) tissue. The results will be compared with immunohistochemical findings (GC and nonGC subtypes) and with cl...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 4 569 tis. Kč
    • •
  • 4 569 tis. Kč
    • •
  • MZ
Project

The analysis of molecular subtypes of diffuse large B-cell lymphoma by high-resolution arrayCGH for determination of genetic changes of prognostic importance (NT11103)

The study of genetic changes in cells of the tumor genome of patients with DLBCL using the array CGH, Q-RT-PCR and immunohistochemistry methods to acquire and the FOXP1 gene, chromosome 8 and the CMYC gene, and chromosome 18q and the BCL2 ge...

FD - Onkologie a hematologie

  • 2010 - 2014
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  • 6 499 tis. Kč
    • •
  • 6 479 tis. Kč
    • •
  • MZ
Project

Complex analysis of p53 mutants in lymphoproliferative diseases (NT13784)

We propose to perform complex analysis of the p53 tumor suppressor in tumor tissues of MCL and DLBCL patients aiming to extend existing panels of patients (from 42 to 70 in MCL and from 75 to 140 in DLBCL) and to determine the progn...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 4 104 tis. Kč
    • •
  • 4 104 tis. Kč
    • •
  • MZ
Project

Investigation of pathophysiology of human leukemias/lymphomas during manipulation of oncogenic microRNAs. (NS10310)

Translational research in hemato-oncology focused on identification of leukemia pathogenesis. Human chronic lymphocytic leukemia (CLL), difuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML) are newly characterized by...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 6 232 tis. Kč
    • •
  • 6 232 tis. Kč
    • •
  • MZ
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