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5 (0,091s)

Project

Effect of acyclic nucleosid phosphonates and other antimetabolites against plant viruses (GA522/09/0707)

The project will study the effect of synthetic inhibitors of polymerases on replication and movement of viruses in plants. The project will be the first assessment of phytotoxicity and antiviral activity of acyclic nucleosid phosphonates (ANPs), PMEA...

EE - Mikrobiologie, virologie

  • 2009 - 2011
  • 2 773 tis. Kč
  • 2 773 tis. Kč
  • GA ČR
Project

Compounds with specific affinity towards V3 loop of gpl20 glycoprotein novel potential inhibitors of HIV -1. (IZ3313)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1995 - 1997
  • 1 790 tis. Kč
  • 1 313 tis. Kč
  • MZ
Project

Novel phosphonate oligonucleotide inhibitors of retroviral integrases (NL5441)

Novel enzyme-atable, phosphonate-based oligonucleotides will prepared and their use as potential HIV-lintegrase inhibitors evaluated.Projects combines chemical synthesis and molecular biology techniques.......

EB - Genetika a molekulární biologie

  • 1999 - 2001
  • 4 005 tis. Kč
  • 2 167 tis. Kč
  • MZ
Project

Design, synthesis and biological evaluation of potential modulators of human adenylate cyclases (LTAUSA18086)

nukleoside phosphonates (ANPs): a) a series of ANPs bearing non-purine nucleobases, b...

Organic chemistry

  • 2019 - 2022
  • 8 213 tis. Kč
  • 7 045 tis. Kč
  • MŠMT
Project

Development of methods for configuration determination at chiral sulfur, nitrogen or phosphorus atom using NMR spectroscopy and ab initio calculations (GA203/09/1919)

The development of a suitable methodology for configuration determination of chiral biologically active compounds containing sulfur, nitrogen, or phosphorus atom as a chiral center (sulfoxides, N-oxides, phosphine oxides, phosphinates and phosphonate...

CC - Organická chemie

  • 2009 - 2011
  • 1 717 tis. Kč
  • 1 717 tis. Kč
  • GA ČR
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