Autocrine effects of visfatin on hepatocyte sensitivity to insulin action

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F10%3A00002297" target="_blank" >RIV/00023001:_____/10:00002297 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/10:00347884 RIV/61388971:_____/10:00347884 RIV/60461373:22330/10:00024459

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Autocrine effects of visfatin on hepatocyte sensitivity to insulin action

Original language description

Visfatin was originally described as an adipokine with insulin mimetic effects. Recently, it was found that visfatin is identical with the Nampt (nicotinamide phosphoribosyltransferase) gene that codes for an intra- and extracellular NAD biosynthetic enzyme and is predominantly expressed outside adipose tissue. In the current study, we found strong protein and mRNA expression of visfatin in rat heart, liver, kidney, and muscle while the expression of visfatin in visceral fat was significantly lower andundetectable in subcutaneous fat. The insulin-mimetic effects on visfatin (extracellular form of Nampt or eNampt) are controversial and even less is known about autocrine effects of visfatin (intracellular form of Nampt or iNampt). Since liver plays themajor role in glucose metabolism, we studied visfatin effects on insulin stimulated cellular glucose uptake in Fao rat hepatocytes using RNA interference (RNAi). RNAi mediated down regulation of the visfatin expression in Fao cells was as

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

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UT code for WoS article

000282054700016

EID of the result in the Scopus database

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