Lipasin/betatrophin is differentially expressed in liver and white adipose tissue without association with insulin resistance in wistar and Goto-Kakizaki rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00075884" target="_blank" >RIV/00023001:_____/17:00075884 - isvavai.cz</a>

Alternative codes found

RIV/00064190:_____/17:N0000082

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/66/66_273.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/66/66_273.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Lipasin/betatrophin is differentially expressed in liver and white adipose tissue without association with insulin resistance in wistar and Goto-Kakizaki rats

Original language description

Lipasin is a recently identified lipokine expressed predominantly in liver and in adipose tissue. It was linked to insulin resistance in mice and to type 1 and type 2 diabetes (T1D, T2D) in humans. No metabolic studies concerning lipasin were performed yet in rats. Therefore, we used rat model of T2D and insulin resistance, Goto-Kakizaki (GK) rats, to determine changes of lipasin expression in liver and in white adipose tissue (WAT) over 52 weeks in the relation to glucose tolerance, peripheral tissue insulin sensitivity and adiposity. GK rats were grossly glucose intolerant since the age of 6 weeks and developed peripheral insulin resistance at the age of 20 weeks. Expression of lipasin in the liver did not differ between GK and Wistar rats, declining with age, and it was not related to hepatic triacylglycerol content. In WAT, the lipasin expression was significantly higher in Wistar rats where it correlated positively with adiposity. No such correlation was found in GK rats. In conclusion, lipasin expression was associated neither with a mild age-related insulin resistance (Wistar), nor with severe genetically-based insulin resistance (GK).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/GA13-06666S" target="_blank" >GA13-06666S: Morphology and function of ß-cell mitochondria in the pathogenesis of type-2 diabetes</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

273-281

UT code for WoS article

000404258800010

EID of the result in the Scopus database

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