Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43910374" target="_blank" >RIV/00216208:11120/15:43910374 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/15:00446509 RIV/00023001:_____/15:00059511 RIV/00064190:_____/15:#0001077
Result on the web
<a href="http://dx.doi.org/10.1155/2015/385395" target="_blank" >http://dx.doi.org/10.1155/2015/385395</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2015/385395" target="_blank" >10.1155/2015/385395</a>
Alternative languages
Result language
angličtina
Original language name
Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats
Original language description
Reduced beta cell mass in pancreatic islets (PI) of Goto-Kakizaki (GK) rats is frequently observed in this diabetic model, but knowledge on delta cells is scarce. Aiming to compare delta cell physiology/pathology of GK to Wistar rats, we found that deltacell number increased over time as did somatostatin mRNA and delta cells distribution in PI is different in GK rats. Subtle changes in 6-week-old GK rats were found. With maturation and aging of GK rats, disturbed cytoarchitecture occurred with irregular beta cells accompanied by delta cell hyperplasia and loss of pancreatic polypeptide (PPY) positivity. Unlike the constant glucose-stimulation index for insulin PI release in Wistar rats, this index declined with GK age, whereas for somatostatin it increased with age. A decrease of GK rat PPY serum levels was found. GK rat body weight decreased with increasing hyperglycemia. Somatostatin analog octreotide completely blocked insulin secretion, impaired proliferation at low autocrine insu
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA13-06666S" target="_blank" >GA13-06666S: Morphology and function of ß-cell mitochondria in the pathogenesis of type-2 diabetes</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Diabetes Research
ISSN
2314-6745
e-ISSN
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Volume of the periodical
2015
Issue of the periodical within the volume
Article ID 385395
Country of publishing house
EG - EGYPT
Number of pages
16
Pages from-to
1-16
UT code for WoS article
000358227300001
EID of the result in the Scopus database
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