Semaphorin 3C is a novel adipokine linked to extracellular matrix composition
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907498" target="_blank" >RIV/00216208:11120/13:43907498 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00125-013-2931-z" target="_blank" >http://dx.doi.org/10.1007/s00125-013-2931-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00125-013-2931-z" target="_blank" >10.1007/s00125-013-2931-z</a>
Alternative languages
Result language
angličtina
Original language name
Semaphorin 3C is a novel adipokine linked to extracellular matrix composition
Original language description
Alterations in white adipose tissue (WAT) function, including changes in protein (adipokine) secretion and extracellular matrix (ECM) composition, promote an insulin-resistant state. We set out to identify novel adipokines regulated by body fat mass in human subcutaneous WAT with potential roles in adipose function. Adipose transcriptome data and secretome profiles from conditions with increased/decreased WAT mass were combined. WAT donors were predominantly women. In vitro effects were assessed using recombinant protein. Results were confirmed by quantitative PCR/ELISA, metabolic assays and immunochemistry in human WAT and adipocytes. We identified a hitherto uncharacterised adipokine, semaphorin 3C (SEMA3C), the expression of which correlated significantly with body weight, insulin resistance (HOMA of insulin resistance [HOMA(IR)], and the rate constant for the insulin tolerance test [K-ITT]) and adipose tissue morphology (hypertrophy vs hyperplasia). SEMA3C was primarily found in ma
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetologia
ISSN
0012-186X
e-ISSN
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Volume of the periodical
56
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1792-1801
UT code for WoS article
000321285400015
EID of the result in the Scopus database
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