Epithelial cells modulate genes associated with NF kappa B activation in co-cultured human macrophages

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002482" target="_blank" >RIV/00023001:_____/11:00002482 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.imbio.2011.04.009" target="_blank" >http://dx.doi.org/10.1016/j.imbio.2011.04.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.imbio.2011.04.009" target="_blank" >10.1016/j.imbio.2011.04.009</a>

Result language

angličtina

Original language name

Epithelial cells modulate genes associated with NF kappa B activation in co-cultured human macrophages

Original language description

Macrophages located in airways and the alveolar space are continually exposed to different signals from the respiratory mucosa. In this respect, epithelial cells represent an important source of cytokines and mediators modulating the state of activationand/or differentiation of mononuclear phagocytes. Many of the proinflammatory genes induced in macrophages during immune and immunopathological reactions are regulated by transcription factor NF kappa B. The aim of our study was to characterize changes in the expression of genes associated with NF kappa B activation and signalling in THP-1 human macrophages co-cultured with A549 respiratory epithelial cells. At least 4-fold upregulation of mRNA level was found in 29 of 84 tested genes including genes for multiple cytokines and chemokines, membrane antigens and receptors, and molecules associated with NF kappa B signalling. The mRNA induction was confirmed at the level of protein expression by evaluating the release of IL-6 and IL-8 and

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Immunobiology

ISSN

0171-2985

e-ISSN

—

Volume of the periodical

216

Issue of the periodical within the volume

10

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

1110-1116

UT code for WoS article

000296365700006

EID of the result in the Scopus database

—