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Epithelial cells modulate genes associated with NF kappa B activation in co-cultured human macrophages

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002482" target="_blank" >RIV/00023001:_____/11:00002482 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.imbio.2011.04.009" target="_blank" >http://dx.doi.org/10.1016/j.imbio.2011.04.009</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.imbio.2011.04.009" target="_blank" >10.1016/j.imbio.2011.04.009</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Epithelial cells modulate genes associated with NF kappa B activation in co-cultured human macrophages

  • Original language description

    Macrophages located in airways and the alveolar space are continually exposed to different signals from the respiratory mucosa. In this respect, epithelial cells represent an important source of cytokines and mediators modulating the state of activationand/or differentiation of mononuclear phagocytes. Many of the proinflammatory genes induced in macrophages during immune and immunopathological reactions are regulated by transcription factor NF kappa B. The aim of our study was to characterize changes in the expression of genes associated with NF kappa B activation and signalling in THP-1 human macrophages co-cultured with A549 respiratory epithelial cells. At least 4-fold upregulation of mRNA level was found in 29 of 84 tested genes including genes for multiple cytokines and chemokines, membrane antigens and receptors, and molecules associated with NF kappa B signalling. The mRNA induction was confirmed at the level of protein expression by evaluating the release of IL-6 and IL-8 and

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Immunobiology

  • ISSN

    0171-2985

  • e-ISSN

  • Volume of the periodical

    216

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    7

  • Pages from-to

    1110-1116

  • UT code for WoS article

    000296365700006

  • EID of the result in the Scopus database