Perivascular sirolimus-delivery system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002495" target="_blank" >RIV/00023001:_____/11:00002495 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/11:00358898 RIV/61388971:_____/11:00358898 RIV/61389013:_____/11:00358898 RIV/67985891:_____/11:00358898
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijpharm.2010.11.005" target="_blank" >http://dx.doi.org/10.1016/j.ijpharm.2010.11.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2010.11.005" target="_blank" >10.1016/j.ijpharm.2010.11.005</a>
Alternative languages
Result language
angličtina
Original language name
Perivascular sirolimus-delivery system
Original language description
Autologous vein grafts are often used for treating damaged vessels, e.g. arteriovenous fistulas or arterial bypass conduits. Veins have a different histological structure from arteries, which often leads to intimal hyperplasia and graft restenosis. The aim of this study was to develop a perivascular sirolimus-delivery system that would release the antiproliferative drug sirolimus in a controlled manner. Polyester Mesh I was coated with purasorb, i.e. a copolymer of L-lactide and epsilon-caprolactone, with dissolved sirolimus; Mesh II was coated with two copolymer layers; the layer with dissolved sirolimus was overlaid with pure purasorb. This arrangement allowed sirolimus to be released for 6 and 4 weeks, for Mesh I and Mesh II, respectively. Mesh II released sirolimus more homogeneously, without the initial burst effect during the first week. However, the cumulative release curve was steeper at later time points than the curve for Mesh I. Both meshes inhibited proliferation of rat vas
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International journal of pharmaceutics
ISSN
0378-5173
e-ISSN
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Volume of the periodical
404
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
94-101
UT code for WoS article
000289220400012
EID of the result in the Scopus database
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