A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00056297" target="_blank" >RIV/00023001:_____/12:00056297 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/12:00385280 RIV/61389013:_____/12:00385280
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0378517312001731" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0378517312001731</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpharm.2012.02.023" target="_blank" >10.1016/j.ijpharm.2012.02.023</a>

Result language
angličtina
Original language name
A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study
Original language description
The main complication of aortocoronary reconstruction with vein grafts is restenosis in the course of time. The aim was to assess the effect of a periadventitial polyester mesh releasing sirolimus on intimal hyperplasia of autologous grafts. We implantedv. jugularis ext. into a. carotis communis in rabbits. The vein graft was either intact, or was wrapped with a pure polyester mesh, or with a sirolimus-releasing mesh. Three and six weeks after surgery, the veins were subjected to standard histologicalstaining and the thicknesses of the tunica intima, the media and the intima-media complex were measured. Wrapping the vein with a mesh releasing sirolimus or with a pure mesh decreased the thickness of the intima in comparison with a vein graft by 73 +/-11% or 73 +/- 8% after 3 weeks, and by 73 +/- 9% or 59 +/- 12% after 6 weeks, respectively. Sirolimus-releasing meshes reduced the thickness of the media by 65 +/- 9% and 20 +/- 12% after 3 and 6 weeks. The thickness of the intima-media
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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