The association between subclinical atherosclerosis in carotid arteries and Connexin 37 gene polymorphism (1019C > T; Pro319Ser) in women

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F11%3A00002513" target="_blank" >RIV/00023001:_____/11:00002513 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The association between subclinical atherosclerosis in carotid arteries and Connexin 37 gene polymorphism (1019C > T; Pro319Ser) in women

Original language description

Aim. The aim of our study was to evaluate a possible association between subclinical atherosclerosis in carotid arteries and the connexin 37 gene polymorphism (1019C>T; Pro319Ser) in a population of urban and rural women. Methods: A 5% population sampleof urban women aged 4554 years (N.=896) and a 1% representative sample of rural women aged 33-72 years (N.=152) were examined using an identical protocol and genotyped for Cx37 gene polymorphism. The association between the Cx37 polymorphism and intima-media thickness in common carotid arteries measured by ultrasound (CIMT) was studied. Results. We have found a different pattern of the effect of the Cx37 gene on CIMT with regard to fasting glycemia with significant interaction between fasting glycemia and Cx37 gene on CIMT (test for equality of slopes P<0.0001). In addition, we also detected potential threshold effect of fasting glycemia at the concentration of 5.5 mmol/L (AN-COVA; P=0.026). Carriers of TT genotype showed protection aga

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/NR9026" target="_blank" >NR9026: Genetic Predisposition to Vascular Complications of Type 1 and Type 2 Diabetes Mellitus in Women</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Angiology

ISSN

0392-9590

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

3

Country of publishing house

IT - ITALY

Number of pages

6

Pages from-to

221-226

UT code for WoS article

000293497400003

EID of the result in the Scopus database

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