Lack of an Association Between Three Tagging SNPs Within the FTO Gene and Smoking Behavior

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00055832" target="_blank" >RIV/00023001:_____/12:00055832 - isvavai.cz</a>
Result on the web
<a href="http://ntr.oxfordjournals.org/content/14/8/998.long" target="_blank" >http://ntr.oxfordjournals.org/content/14/8/998.long</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/ntr/ntr255" target="_blank" >10.1093/ntr/ntr255</a>

Result language
angličtina
Original language name
Lack of an Association Between Three Tagging SNPs Within the FTO Gene and Smoking Behavior
Original language description
Introduction: Using genome-wide screening, a polymorphism within the second intron of the FTO gene (rs2302673) was found to be associated with smoking habits in females. In a population-based, cross-sectional study, we analyzed three tagging FTO single-nucleotide polymorphisms (SNPs) for their association with smoking behavior. Methods: Subjects from the Czech post-MONICA study, including 1,191 adult males (32.1% smokers) and 1,368 adult females (22.5% smokers) were included in this study. Smoking habits were obtained through questionnaire data analysis, and three FTO tagging SNPs were genotyped (rs17817449: intron 1, rs2302673: intron 2, and rs17818902: intron 3). Results: We detected slightly lower frequencies (p = .043) of the GG genotype of the rs17818902 SNP in males who quit smoking compared with others. However, the significance disappeared after adjusting for multiple testing. Within the entire population, or in either males or females alone, we failed to detect a significant d
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
<a href="/en/project/NT12170" target="_blank" >NT12170: Genetic determination of the nicotine dependence and the efficaccy of the nicotine dependence treatment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)