The association between the FTO gene variant and alcohol consumption and binge and problem drinking in different gene-environment background: The HAPIEE study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078042" target="_blank" >RIV/00023001:_____/19:00078042 - isvavai.cz</a>

Result on the web

<a href="https://reader.elsevier.com/reader/sd/pii/S0378111919304573?token=BCA057E3B3B4502C166360357DE1CCD05CEF3405F16C9A630781581D00936B9603AD667D2CE66F42D674D3F85084E16D" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0378111919304573?token=BCA057E3B3B4502C166360357DE1CCD05CEF3405F16C9A630781581D00936B9603AD667D2CE66F42D674D3F85084E16D</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.gene.2019.05.002" target="_blank" >10.1016/j.gene.2019.05.002</a>

Result language

angličtina

Original language name

The association between the FTO gene variant and alcohol consumption and binge and problem drinking in different gene-environment background: The HAPIEE study

Original language description

Background: Alcohol intake and tobacco smoking have significant negative health consequences and both are influenced by genetic predispositions. Some studies suggest that the FTO gene is associated with alcohol consumption. We investigated whether a tagging variant (rs17817449) within the FTO gene is associated with alcohol intake, problem drinking and smoking behaviour. Methods: We analysed data from 26,792 Caucasian adults (47.2% of males; mean age 58.9 (+/- 7.3) years), examined through the prospective cohort HAPIEE study. The primary outcomes were daily alcohol consumption, binge drinking, problem drinking (CAGE score 2+) and smoking status in relation to tagging variants within the F7&apos;0 and ADH1B genes. Results: We found no significant association of the FTO polymorphism with smoking status in either sex. The associations of the FTO polymorphism with drinking pattern were inconsistent and differed by gender. In men, GG homozygote carriers had lower odds of problem drinking (OR 0.85, 95% CI 0.75-0.96, p = 0.03). In women, the combination of the FTO/ADH1B GG/+A genotypes doubled the risk of binge drinking (OR 2.10, 95% CI 1.19-3.71, p &lt; 0.05), and the risk was further increased among smoking women (OR 4.10, 95% CI 1.64-10.24, p = 0.008). Conclusions: In this large population study, the FTO gene appeared associated with binge and problem drinking, and the associations were modified by sex, smoking status and the ADH1B polymorphism.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10603 - Genetics and heredity (medical genetics to be 3)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Gene

ISSN

0378-1119

e-ISSN

—

Volume of the periodical

707

Issue of the periodical within the volume

July 30

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

30-35

UT code for WoS article

000471355900004

EID of the result in the Scopus database

2-s2.0-85065398795