Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059048" target="_blank" >RIV/00023001:_____/14:00059048 - isvavai.cz</a>
Alternative codes found
RIV/75010330:_____/14:00010724
Result on the web
<a href="http://www.bmj.com/content/349/bmj.g4164.full.pdf+html" target="_blank" >http://www.bmj.com/content/349/bmj.g4164.full.pdf+html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/bmj.g4164" target="_blank" >10.1136/bmj.g4164</a>

Result language
angličtina
Original language name
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data
Original language description
Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Design Mendelian randomisation meta-analysis of 56 epidemiological studies. Participants 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. Main outcome measures Odds ratio forcoronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption. Results Carriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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