Aldehyde dehydrogenase 2 polymorphism affects the outcome of methanol poisoning in exposed humans

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10381969" target="_blank" >RIV/00216208:11110/18:10381969 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/18:00077323 RIV/00064165:_____/18:10381969

Result on the web

<a href="https://doi.org/10.1111/cge.13411" target="_blank" >https://doi.org/10.1111/cge.13411</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cge.13411" target="_blank" >10.1111/cge.13411</a>

Result language

angličtina

Original language name

Aldehyde dehydrogenase 2 polymorphism affects the outcome of methanol poisoning in exposed humans

Original language description

As the susceptibility of humans to xenobiotics often depends on genetic factors, we assumed that ADH1B and ALDH2 genetic variants may affect susceptibility to the acute methanol exposure. To evaluate the role of genetic variants of enzymes involved in methanol catabolism in humans, we analysed ADH1B (rs1229984) and ALDH2 (rs441) polymorphisms in 50 adults who survived acute methanol poisoning, 246 individuals with alcoholic liver cirrhosis, and in 545 healthy controls. GG homozygotes of ADH1B were more common among methanol-poisoned patients (98%) and among patients with alcoholic liver cirrhosis (98%) than among healthy controls (90%) (P = 0.08 and&lt; 0.001, respectively). Minor C allele carriers of the ALDH2 were significantly more common among methanol-poisoned persons (46%) than among patients with alcoholic liver cirrhosis or healthy controls (31% in both groups, P &lt; 0.05 and 0.025, respectively); the odds ratios were 1.89 (95% CI 1.02-3.52) and 1.94 (1.08-3.48), respectively. As there was a substantial amount of subjects with alcohol abuse between both groups of patients, ADH1B is unlikely to affect the susceptibility to methanol poisoning. By contrast, the genetic variant of the ALDH2 enzyme seems to specifically affect the susceptibility to methanol in acutely exposed humans and potentially plays a role in the outcome of methanol poisoning.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30108 - Toxicology

Project

<a href="/en/project/NV16-27075A" target="_blank" >NV16-27075A: NEURODEGENERATIVE PROCESSES IN PATIENTS EXPOSED TO METHANOL: PROSPECTIVE STUDY AFTER CZECH MASS METHANOL POISONING OUTBREAK IN 2012</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Genetics

ISSN

0009-9163

e-ISSN

—

Volume of the periodical

94

Issue of the periodical within the volume

5

Country of publishing house

DK - DENMARK

Number of pages

5

Pages from-to

445-449

UT code for WoS article

000446554800006

EID of the result in the Scopus database

2-s2.0-85050913999