Rare Alleles within the CYP2E1 (MEOS System) Could be Associated with Better Short-Term Health Outcome after Acute Methanol Poisoning

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10282057" target="_blank" >RIV/00216208:11110/15:10282057 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/15:00059246 RIV/00064165:_____/15:10282057

Result on the web

<a href="http://dx.doi.org/10.1111/bcpt.12310" target="_blank" >http://dx.doi.org/10.1111/bcpt.12310</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bcpt.12310" target="_blank" >10.1111/bcpt.12310</a>

Result language

angličtina

Original language name

Rare Alleles within the CYP2E1 (MEOS System) Could be Associated with Better Short-Term Health Outcome after Acute Methanol Poisoning

Original language description

Genetic polymorphisms influence the metabolism of ethanol and methanol, but the potential effects of genetic predisposition on the clinical course, outcome and short-term health sequelae of acute methanol poisoning are unknown. To evaluate the role of the MEOS system in methanol poisoning, we analysed the effect of three polymorphisms (RsaI - rs2031920; PstI - rs3813867; insertion/deletion I/D) within the CYP2E1 enzyme (MEOS system) in 50 adult survivors of methanol poisoning and compared their genotypefrequencies with 460 controls. The minor allele frequencies of all three polymorphisms were below 5% in both groups. We did not detect significant differences in the genotype frequencies between survivors of methanol poisoning and controls (p=0.34 for the RsaI variant; p=0.59 for the PstI variant and p=0.21 for the I/D polymorphism). The carriers of at least one minor allele in the CYP2E1 gene had less severe clinical symptoms and better short-term outcome after acute poisoning. Variant

Czech name

—

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Basic and Clinical Pharmacology and Toxicology

ISSN

1742-7835

e-ISSN

—

Volume of the periodical

116

Issue of the periodical within the volume

2

Country of publishing house

DK - DENMARK

Number of pages

5

Pages from-to

168-172

UT code for WoS article

000348497700012

EID of the result in the Scopus database

2-s2.0-84921279364