Distribution of adh1b genotypes predisposed to enhanced alcohol consumption in the Czech roma/gypsy population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F18%3A43898332" target="_blank" >RIV/60076658:12110/18:43898332 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/18:00077631 RIV/68407700:21460/18:00340653

Result on the web

<a href="http://dx.doi.org/10.21101/cejph.a5090" target="_blank" >http://dx.doi.org/10.21101/cejph.a5090</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21101/cejph.a5090" target="_blank" >10.21101/cejph.a5090</a>

Result language

angličtina

Original language name

Distribution of adh1b genotypes predisposed to enhanced alcohol consumption in the Czech roma/gypsy population

Original language description

Objective: The aim of the study was to analyse the frequencies of rs1229984 genotypes within the alcohol dehydrogenase (ADH1B) gene in a Gypsies/Roma population and compare them with other populations and with ethanol consumption. Methods: We analysed the ADH1B (rs1229984; Arg47→His; c.143G&gt;A) genotype using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) in two ethnically different groups – Gypsies/Roma (N = 301) and Czechs (N = 300) where one day alcohol consumption was recorded. Results: ADH1B genotype/allelic frequencies did not significantly differ between the populations (p = 0.32). The frequency of minor A allele carriers was slightly higher in Gypsies/Roma (14.7%) than in Czechs (11.9%). The prevalence of subjects reporting alcohol intake on the previous day was non-significantly lower in Gypsies/Roma (10.5% vs. 16.4%), as was the amount of alcohol consumed the day before the examination in ethanol consumers (36.1 ± 18.3 g vs. 43.0 ± 27.2 g). Conclusions: The frequency of rs1229984 genotypes in the ADH1B gene within the Gypsies/Roma population corresponds with frequencies obtained in North India/Central Asia, the putative country of this ethnic origin. Our results suggest that the minority Gypsies/Roma population consume slightly less alcohol than the Czech majority population. © 2018, Czech National Institute of Public Health. All rights reserved.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30101 - Human genetics

Project

<a href="/en/project/LD14114" target="_blank" >LD14114: Obesity and overweight in Romany minority in the Region of South Bohemia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central European Journal of Public Health

ISSN

1210-7778

e-ISSN

—

Volume of the periodical

26

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

284-288

UT code for WoS article

000463167100007

EID of the result in the Scopus database

2-s2.0-85060137955