Frequency of adult type-associated lactase persistence LCT-13910C/T genotypes in the Czech/Slav and Czech Roma/Gypsy populations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F17%3A00329140" target="_blank" >RIV/68407700:21460/17:00329140 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12110/17:43896855 RIV/00023001:_____/17:00075951

Result on the web

<a href="http://dx.doi.org/10.1590/1678-4685-GMB-2016-0071" target="_blank" >http://dx.doi.org/10.1590/1678-4685-GMB-2016-0071</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1590/1678-4685-GMB-2016-0071" target="_blank" >10.1590/1678-4685-GMB-2016-0071</a>

Result language

angličtina

Original language name

Frequency of adult type-associated lactase persistence LCT-13910C/T genotypes in the Czech/Slav and Czech Roma/Gypsy populations

Original language description

Lactase non-persistence (leading to primary lactose intolerance) is a genetically dependent inability to digest lactose in adulthood. As part of the human adaptation to dairying, the human lactase LCT-13910C/T mutation (which propagates adult expression of lactase) developed, spread and participated in the adaptation to dairying. This variant is associated with lactase activity persistence, and its carriers are able to digest lactose. We compared the frequencies of lactase 13910C/T (rs4988235) genotypes in Czechs/Slavs (N = 288) and Czech Gypsies/Roma (N = 300), two ethnically different groups where this polymorphism has not yet been analysed. Allelic frequencies significantly differed between the populations (p < 0.0001). In Czechs/Slavs, the lactase persistence T allele was present in 76% of the individuals, which is in agreement with frequencies among geographically neighbouring populations. In the Czech Gypsy/Roma population, only 27% of the adults were carriers of at least one lactase persistence allele, similar to the Indian population. In agreement with this result, dairy product consumption was reported by 70.5% of Czechs/Slavs and 39.0% of the Czech Gypsy/Roma population. Both in the Czech Gypsy/Roma and in the Czech/Slavs populations, the presence of carriers of the lactase persistence allele was similar in subjects self-reporting the consumption of unfermented/fresh milk, in comparison to the others.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30308 - Nutrition, Dietetics

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genetics and Molecular Biology

ISSN

1415-4757

e-ISSN

1678-4685

Volume of the periodical

40

Issue of the periodical within the volume

2

Country of publishing house

BR - BRAZIL

Number of pages

3

Pages from-to

450-452

UT code for WoS article

000404114600009

EID of the result in the Scopus database

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