Alloimmunosensitization in Left Ventricular Assist Device Recipients and Impact on Posttransplantation Outcome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00056070" target="_blank" >RIV/00023001:_____/12:00056070 - isvavai.cz</a>

Result on the web

<a href="http://journals.lww.com/asaiojournal/pages/articleviewer.aspx?year=2012&issue=11000&article=00005&type=abstract" target="_blank" >http://journals.lww.com/asaiojournal/pages/articleviewer.aspx?year=2012&issue=11000&article=00005&type=abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MAT.0b013e31826d6070" target="_blank" >10.1097/MAT.0b013e31826d6070</a>

Result language

angličtina

Original language name

Alloimmunosensitization in Left Ventricular Assist Device Recipients and Impact on Posttransplantation Outcome

Original language description

Left ventricular assist devices (LVADs) have become an established surgical therapy for patients with end-stage heart failure who require hemodynamic support as a bridge-to-transplant or destination therapy. However, the anatomic and physiologic consequences of long-term LVAD support have yet to be fully clarified. Despite the clinical success of these devices, it has been reported that many patients bridged to transplantation with mechanical support develop circulating antibodies with potential donor reactivity. Transplanting against existing or historic donor-specific antibodies is associated with increased risk of antibody-mediated rejection, graft dysfunction, and decreased survival. Safe transplantation of allosensitized patients is dependent on using prospective crossmatching and antibody titer reduction techniques (desensitization). Strict protocols requiring a negative prospective crossmatch before transplantation result in a decreased donor pool and a longer duration of suppor

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ASAIO Journal

ISSN

1058-2916

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

554-561

UT code for WoS article

000310580400005

EID of the result in the Scopus database

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